Association of prenatal and perinatal complications with subsequent bipolar disorder and schizophrenia
Association of prenatal and perinatal complications with subsequent bipolar disorder and schizophrenia
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DOI：
10.1016/s0920-9964(99)00109-7
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发表时间：
1999-09-29
影响因子：
4.5
通讯作者：
Fan, AP
中科院分区：
文献类型：
--
作者：
Buka, SL;Fan, AP
本文概述了最近关于产前和围产期并发症（PPCs）与精神分裂症之间关系的文献，然后系统地回顾了1965年以后发表的关于PPCs与双相情感障碍之间关系的论文。四项比较双相情感障碍病例与正常对照的研究中有三项表明，PPCs与成年后双相情感障碍的发展呈正相关；比值比为1.0 ~ 12.0。无对照对象的双相患者中PPCs的比例为3.8% ~ 50.0%。讨论了研究设计、测量、暴露程度和结果等问题。这篇综述表明，有必要进一步研究PPCs与精神分裂症以外的精神障碍之间的遗传相互作用、性别差异和特异性效应。(C) 1999 Elsevier Science B.V.版权所有
This paper presents an overview of the recent literature on the association between prenatal and perinatal complications (PPCs) and schizophrenia, then systematically reviews papers published later than 1965 examining the association of PPCs and bipolar disorder. Three of the four studies comparing bipolar cases with normal controls indicated a positive association of PPCs with the development of bipolar disorder in adult life; the four odds ratios ranged from 1.0 to 12.0. The proportion of PPCs among the bipolar samples without comparison subjects ranged from 3.8% to 50.0%. Issues of study design, measurement and severity of exposure, and outcome are addressed. This review suggests that further investigation of genetic interactions, gender differences, and the specificity of effects in the association between PPCs and mental disorders other than schizophrenia is warranted. (C) 1999 Elsevier Science B.V. All rights reserved.