Estimating the impact of changes in weight and BMI on EQ-5D-3L: a longitudinal analysis of a behavioural group-based weight loss intervention.
Estimating the impact of changes in weight and BMI on EQ-5D-3L: a longitudinal analysis of a behavioural group-based weight loss intervention.
复制标题
DOI：
10.1007/s11136-022-03178-z
复制
发表时间：
2022-11
影响因子：
3.5
通讯作者：
Brennan, Alan
中科院分区：
文献类型：
--
作者：
Breeze, Penny;Gray, Laura A.;Thomas, Chloe;Bates, Sarah E.;Brennan, Alan
To estimate the association between changes in BMI and changes in Health-Related Quality of Life (EQ-5D-3L). The WRAP trial was a multicentre, randomised controlled trial with parallel design and recruited 1267 adults (BMI ≥ 28 kg/m2). Participants were allocated to Brief Intervention, a Commercial weight management Programme (WW, formerly Weight Watchers) for 12 weeks, or the same Programme for 52 weeks. Participants were assessed at 0, 3, 12, 24, and 60 months. We analysed the relationship between BMI and EQ-5D-3L, adjusting for age and comorbidities, using a fixed effects model. Test for attrition, model specification and missing data were conducted. Secondary analyses investigated a non-symmetric gradient for weight loss vs. regain. A unit increase in BMI was associated with a − 0.011 (95% CI − 0.01546, − 0.00877) change in EQ-5D-3L. A unit change in BMI between periods of observation was associated with − 0.016 017 (95% CI − 0.0077009, − 0.025086) change in EQ-5D-3L. The negative association was reduced during weight loss, as opposed to weight gain, but the difference was not statistically significant. We have identified a strong and statistically significant negative relationship between BMI changes and HRQoL. These estimates could be used in economic evaluations of weight loss interventions to inform policymaking. This trial was registered with Current Controlled Trials, number ISRCTN82857232. The online version contains supplementary material available at 10.1007/s11136-022-03178-z.
登录
查看更多内容
DOI：
10.1016/j.jval.2017.09.017
发表时间：
2018-06
期刊：
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
影响因子：
--
作者：
Gray LA;Hernández Alava M;Wailoo AJ
通讯作者：
Wailoo AJ
影响因子：
4.5
作者：
Ara, Roberta;Brazier, John E.
通讯作者：
Brazier, John E.
影响因子：
3.3
作者：
Brooks, R
通讯作者：
Brooks, R
影响因子：
9.3
作者：
Warkentin, Lindsey M.;Majumdar, Sumit R.;Padwal, Raj S.
通讯作者：
Padwal, Raj S.
影响因子：
4.5
作者：
Kearns, Benjamin;Ara, Roberta;Relton, Clare
通讯作者：
Relton, Clare