Imaging the human hippocampus with optically-pumped magnetoencephalography
Imaging the human hippocampus with optically-pumped magnetoencephalography
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DOI：
10.1016/j.neuroimage.2019.116192
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发表时间：
2019-12-01
期刊：
影响因子：
5.7
通讯作者：
Maguire, Eleanor A.
中科院分区：
文献类型：
--
作者：
Barry, Daniel N.;Tierney, Tim M.;Maguire, Eleanor A.
光泵 (OP) 磁力计允许在参与者的头部不受约束的情况下进行脑磁图 (MEG)。为了充分利用这项新技术，特别是其移动能力，必须使用 OP-MEG 来检测促进导航等探索行为的深层大脑结构的活动。海马体就是这样重要的大脑区域之一。在这里，我们让三名健康的成年参与者在使用 OP-MEG 进行扫描的同时执行一项依赖于海马体的任务——想象新颖的场景图像。对这三名参与者的联合分析揭示了内侧颞叶 θ 功率的显着变化。该激活簇的峰值位于前海马体。我们在传统的 SQUID-MEG 扫描仪中对相同的参与者重复了该实验，发现内侧颞叶有类似的参与，并且在前海马体中也有一个峰值。这些 OP-MEG 研究结果表明，为研究自然背景下一系列关键认知功能的神经相关性提供了令人兴奋的新机会，包括空间导航、情景记忆和社交互动。
Optically-pumped (OP) magnetometers allow magnetoencephalography (MEG) to be performed while a participant's head is unconstrained. To fully leverage this new technology, and in particular its capacity for mobility, the activity of deep brain structures which facilitate explorative behaviours such as navigation, must be detectable using OP-MEG. One such crucial brain region is the hippocampus. Here we had three healthy adult participants perform a hippocampal-dependent task - the imagination of novel scene imagery - while being scanned using OP-MEG. A conjunction analysis across these three participants revealed a significant change in theta power in the medial temporal lobe. The peak of this activated cluster was located in the anterior hippocampus. We repeated the experiment with the same participants in a conventional SQUID-MEG scanner and found similar engagement of the medial temporal lobe, also with a peak in the anterior hippocampus. These OP-MEG findings indicate exciting new opportunities for investigating the neural correlates of a range of crucial cognitive functions in naturalistic contexts including spatial navigation, episodic memory and social interactions.