Shining a Light on Venous Thromboembolism.
Shining a Light on Venous Thromboembolism.
复制标题
照亮静脉血栓栓塞。
DOI：
10.1016/j.jacbts.2020.03.004
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sharma,Aditya
中科院分区：
文献类型：
--
作者：
Kanthi,Yogendra;Sharma,Aditya
临床前研究是开发和检验转化为人类疾病的假说和新方法的重要基础。许多不同的病理过程可导致静脉血栓栓塞症。使用小鼠模型的研究揭示了多种细胞类型的贡献。已经确定了在内皮和血小板激活、中性粒细胞细胞外TRAP生成、髓系衍生组织因子释放和红细胞介导的血栓稳定方面的作用。炎症小体的激活也被描述为在静脉血栓形成中导致聚集性炎症细胞因子IL-1b成熟的关键作用[1]。已经描述了几种检查静脉血栓形成和消退的模型，每种模型都有其优点和局限性。为了帮助研究人员选择合适的模型来检验他们的假说，几个专业学会最近发表了一份共识声明，详细介绍了最广泛使用的深静脉血栓形成(DVT)模型的方法、优缺点(2)。在本期的《美国医学会杂志》上：
Preclinical studies are important grounds to develop and test hypotheses and novel approaches for translation to human disease. A number of distinct pathologic processes can result in venous thromboembolism. Studies using murine models have shed light on contributions from multiple cell types. Roles have been identified for endothelial and platelet activation, neutrophil extracellular trap generation, myeloid-derived tissue factor release, and erythrocyte-mediated thrombus stabilization. Critical roles have also been described for activation of the inflammasome resulting in maturation of the paradigmatic inflammatory cytokine, interleukin-1b, in venous thrombogenesis (1). Several models to examine venous thrombogenesis and resolution have been described, each with strengths and limitations. To help investigators select an appropriate model to test their hypotheses, several professional societies recently published a consensus statement with detailed methodologies, advantages, and disadvantages of the most widely used models of deep vein thrombosis (DVT)(2). In this issue of JACC: