Disparate cardio-cerebral vascular modulation during standing in multiple system atrophy and Parkinson disease
Disparate cardio-cerebral vascular modulation during standing in multiple system atrophy and Parkinson disease
复制标题
DOI：
10.1016/j.jns.2008.09.006
复制
发表时间：
2009-01-15
影响因子：
4.4
通讯作者：
Cui, Li-Ying
中科院分区：
文献类型：
--
作者：
Xu, Wei-Hai;Wang, Han;Cui, Li-Ying
目的：经颅多普勒（TCD）监测脑血流速度（CBFV）的动态变化，可以揭示心脑血管自动调节的综合作用。方法：对22例多系统萎缩（MSA）、20例帕金森病（PD）患者和20例年龄相匹配的健康志愿者，采用经颅多普勒（TCD）记录其大脑中动脉血流速度曲线，并进行统计学分析。所有个体均以仰卧位开始，然后突然站立2分钟，然后恢复仰卧位。结果：健康志愿者站立后CBFV下降，但很快回升，并达到或超过仰卧基线水平。之后，CBFV突然下降到一个持续的水平，低于仰卧基线，形成一个棘波出现在CBFV曲线。MSA组5/22例出现棘波，显著低于PD组（18/20）和正常对照组（20120）（P
Purpose: The dynamic variance of cerebral blood flow velocity (CBFV), monitored by transcranial doppler(TCD), can reveal the integrated effects of cardio-cerebral vascular autoregulation. We investigated the characteristics of CBFV curve during active standing in multiple system atrophy (MSA), Parkinson's disease (PD) and healthy volunteers.Methods: The CBFV curve of middle cerebral arteries was recorded using TCD in 22 patients with probable MSA: 20 PD patients and 20 volunteers matched for age. All individuals started in a supine posture, followed by abrupt standing for 2 min before returning to supine. The features of CBFV curve were compared among the groups.Results: In the healthy volunteers, the CBFV decreased following standing up but quickly rebounded and reached the same or greater level as the supine baseline. Afterwards, the CBFV decreased abruptly to a sustained level, lower than the supine baseline, forming a spike wave that appeared in CBFV curve. This spike wave was present in 5/22 of MSA, significantly less than PD patients (18/20) and volunteers (20120) (P