Birefringence Measurement of Rapid Structural Changes during Collagen Denatu ration
Birefringence Measurement of Rapid Structural Changes during Collagen Denatu ration
复制标题
胶原变性过程中快速结构变化的双折射测量
DOI：
10.1111/j.1751-1097.1998.tb05294.x
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发表时间：
1998
影响因子：
3.3
通讯作者：
J. Walsh
中科院分区：
文献类型：
--
作者：
V. Sankaran;J. Walsh
摘要-线性双折射是一种由材料的结构和成分引起的光学特性，可用于研究组织结构的动态变化。使用Ho：YAG激光器发出的2.1 μm辐射的单次200 μs长脉冲诱导大鼠尾腱线性双折射的变化。这种变化是在毫秒的时间尺度上测量的。描述变性的实测速率系数未通过先前对较慢、较低温度加热诱导的胶原蛋白变性的研究进行预测。激光诱导的胶原蛋白变性可分为两种类型：热变性（表现为速率受限）和热机械变性（在较高的激光辐射暴露下观察到）。这两个过程都不能用标准的Arkidius型动力学模型来描述。
Abstract— Linear birefringence, an optical property that results from a material's structure and composition, can be used to study dynamic changes in tissue structure. Single, 200 μs‐long pulses from a Ho:YAG laser emitting 2.1 μm radiation were used to induce changes in the linear birefringence of rat tail tendon. Such changes were measured on a millisecond timescale. The measured rate coefficients describing the denaturation are not predicted by previous studies of collagen denaturation induced by slower, lower‐temperature heating. Two types of laser‐induced collagen denaturation can be differentiated: thermal denaturation, which appears rate‐limited, and thermomechanical denaturation, which is observed at higher laser radiant exposures. Neither process is described by standard Arrhenius‐type kinetic models.