First proton radiography of an animal patient
First proton radiography of an animal patient
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DOI：
10.1118/1.1690713
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发表时间：
2004-05-01
期刊：
影响因子：
3.8
通讯作者：
Kaser-Hotz, B
中科院分区：
文献类型：
--
作者：
Schneider, U;Besserer, J;Kaser-Hotz, B
这项工作的目的是显示质子射线照相术的辐射剂量，成像速度，图像质量（密度和空间分辨率），和图像内容在临床条件下的可行性。具有214 MeV能量的质子可以穿透大多数患者并用于成像。从射束路径中没有物体的范围中减去患者身后质子的测量剩余范围（或能量），并用于创建投影图像。因此，图像内容与质子在患者体内丢失的范围成比例。我们采取质子图像的头部狗后，它接受质子放射治疗的鼻腔肿瘤。通过分别测量每个质子在患者前方和后方的坐标，空间分辨率约为1 mm。采集时间约为几秒，并受患者检查床移动的限制。图像的范围灵敏度约为0.6 mm，足以将图像用于治疗范围验证。犬在暴露期间接受的剂量为0.03 mGy，比可比X射线图像小约50-100倍。获得质子范围的定量图像的潜力，具有令人满意的空间和范围分辨率和低剂量的患者表明，质子射线照相术应适用于质子放射治疗的患者。(C)2004年美国医学物理学家协会。
The purpose of this work is to show the feasibility of proton radiography in terms of radiation dose, imaging speed, image quality (density and spatial resolution), and image content under clinical conditions. Protons with 214 MeV energy can penetrate through most patients and were used for imaging. The measured residual range (or energy) of the protons behind the patient was subtracted from the range without an object in the beam path and used to create a projected image. The image content is therefore proportional to the range that protons have lost in the patient. We took proton images of the head of a dog after it received proton radiotherapy treatment of a nasal tumor. The spatial resolution by measuring for each proton separately its-coordinate in front of and behind the patient was approximately 1 mm. The acquisition time was on the order of several seconds and was limited by the patient table movement. The range sensitivity of the images was approximately 0.6 mm, which is good enough to use the images for therapy range verification. The dose that the dog received during exposure was 0.03 mGy, which is approximately a factor 50-100 smaller than for a comparable x-ray image. The potential to obtain quantitative images of proton ranges with satisfying spatial and range resolution and low dose to the patient suggests that proton radiography should be applied to patients who are under proton radiotherapy treatment. (C) 2004 American Association of Physicists in Medicine.