Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
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DOI：
10.1016/s0140-6736(98)06244-8
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发表时间：
1999-01-02
期刊：
影响因子：
168.9
通讯作者：
Johnstone, EC
中科院分区：
文献类型：
--
作者：
Lawrie, SM;Whalley, H;Johnstone, EC
背景精神分裂症是一种多因素疾病，与大脑发育紊乱有关。结构性脑成像研究一致表明，大脑某些部分的体积，特别是内侧颞叶，是！精神分裂症患者比健康人小。这些大脑结构异常是否早于症状出现尚不清楚。方法对 100 名精神分裂症高危人群（两名或两名以上一级或二级亲属受影响）、20 名首次精神分裂症发作患者和 30 名健康对照者进行了脑部磁共振成像。通过标准技术测量感兴趣区域的体积。结果发现首发组的平均全脑体积为1356 cm(3) (SD 178)，高危组为1347 cm(3) (122)，1334 cm(3)。 （149）在对照中（p=0.8）。首发组左侧杏仁核-海马复合体 (AHC) 的平均体积 (4.3 cm(3) [0.6]) 低于高危组 (4.6 cm(3) [0.6])，进而低于对照组 (4.8 cm(3) [0.7])；这些差异是显着的（p
Background Schizophrenia is a multifactorial disorder that is associated with disturbed cerebral development, Structural brain-imaging studies have consistently shown that the volumes of some parts of the brain, particularly the mesial temporal lobes, are! smaller in patients with schizophrenia than in healthy people. Whether these abnormalities of brain structure predate the onset of symptoms is not known.Methods 100 people at high risk of developing schizophrenia (two or more first-degree or second-degree relatives affected), 20 patients in their first episode of schizophrenia, and 30 healthy controls underwent magnetic resonance imaging of the brain. The volumes of regions of interest were measured by standard techniques.Findings Mean whole-brain volume was 1356 cm(3) (SD 178) in the first-episode group, 1347 cm(3) (122) in the high-risk group, and 1334 cm(3). (149) in the controls (p=0.8). The mean volume of the left amygdala-hippocampal complex (AHC) was lower in the first-episode group (4.3 cm(3) [0.6]) than in the high-risk group (4.6 cm(3) [0.6]), and in turn than in the controls (4.8 cm(3) [0.7]); these differences were significant (p