THE OCULOBULBAR FACIAL RESPIRATORY SCORE IS A TOOL TO ASSESS BULBAR FUNCTION IN MYASTHENIA GRAVIS PATIENTS
THE OCULOBULBAR FACIAL RESPIRATORY SCORE IS A TOOL TO ASSESS BULBAR FUNCTION IN MYASTHENIA GRAVIS PATIENTS
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DOI：
10.1002/mus.21880
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发表时间：
2011-03-01
期刊：
影响因子：
3.4
通讯作者：
Burns, Ted M.
中科院分区：
文献类型：
--
作者：
Farrugia, Maria E.;Harle, Heather D.;Burns, Ted M.
眼球面部呼吸（OBFR）评分是一种客观测量重症肌无力（MG）患者球功能的工具。在本研究中，我们分析了OBFR与MG日常生活活动（MGADL）评分之间的关系，以及最近描述的MG复合和15项MG生活质量（MG- qol15）量表之间的关系。我们从两个中心招募了42名患者，并使用OBFR、MG Composite、MG- adl和MG- qol15量表对他们进行了两次评估，间隔约6个月。“修改”的OBFR评分来源于原始OBFR评分。OBFR评分与MG综合评分、MG- adl评分和MG- qol15评分均显著相关，并与所有三项评分的球项总和显著相关。它还与所有三个分数的个别球相关项目密切相关。“修改后”的OBFR得分也与上述所有得分显著相关。本研究证实了OBFR和“修正”OBFR评分的结构效度。中国生物医学工程学报，2011
The Oculobulbar Facial Respiratory (OBFR) score is a tool that objectively measures bulbar function in myasthenia gravis (MG). In this study, we analyzed the relation between the OBFR and the MG Activities of Daily Living (MGADL) score, and also with the more recently described MG Composite and 15-item MG Quality-of-Life (MG-QOL15) scales. We recruited 42 patients from two centers and assessed them on two occasions, approximately 6 months apart, using the OBFR, MG Composite, MG-ADL, and MG-QOL15 scales. The 'modified' OBFR score was derived from the original OBFR score. The OBFR score correlated significantly with the MG Composite, MG-ADL, and MG-QOL15 scores for both assessments, and with the sum of the bulbar items for all three scores. It also correlated strongly with the individual bulbar-related items of all three scores. The 'modified' OBFR score also correlated significantly with all the aforementioned scores. This study confirmed construct validity of the OBFR and 'modified' OBFR scores. Muscle Nerve 43:329-334, 2011