Young smokers' views of genetic susceptibility testing for lung cancer risk: minding unintended consequences.
Young smokers' views of genetic susceptibility testing for lung cancer risk: minding unintended consequences.
复制标题
年轻吸烟者对肺癌风险基因易感性检测的看法：注意意外后果。
DOI：
10.1007/s12687-011-0053-1
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发表时间：
2011
影响因子：
1.9
通讯作者：
Lipkus,IsaacM
中科院分区：
文献类型：
--
作者：
Docherty,SharronL;McBride,ColleenM;Sanderson,SaskiaC;O'Neill,SuzanneC;Shepperd,JamesA;Lipkus,IsaacM
Assessment of smokers’ responses to individualized feedback of genetic susceptibility has shown little or no influence on smoking cessation outcomes. One explanation is that smokers may be having unintended responses that undermine the feedback’s motivational impact (e.g., fatalism or downplaying risk). In preparation for a large randomized trial with college smokers, we conducted a qualitative pilot study to explore smokers’ motives for genetic testing and how these motives might influence interpretation of genetic risk feedback. Prior to reviewing informational materials describing a test for the glutathioneS-transferase M1 gene, 33 college smokers (18 to 21 years) participated in a 30-min, semistructured, open-ended interview regarding their attitudes on health risks, genetic testing in general, genetic testing for lung cancer risk, and informational needs regarding genetics and genetic testing for lung cancer risk. Two central themes emerged from an analysis of the interviews: general impressions of genetic testing and perceived value of genetic testing. Prominent in the second theme was the finding that genetic risk feedback may be unsuccessful in motivating quitting (a) due to skepticism about genetic tests, (b) participants dismissing genetic feedback as personally irrelevant, and (c) participants receiving low-risk results justifying continued smoking in light of public health messages that “it’s never too late to quit.” These findings require careful consideration among health professionals looking to genetic risk feedback as a vehicle to motivate disease prevention or behavior change.
