Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.
Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.
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DOI：
10.1177/1744806918815005
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发表时间：
2018-01
期刊：
影响因子：
3.3
通讯作者：
Yaksh TL
中科院分区：
文献类型：
--
作者：
Shubayev VI;Strongin AY;Yaksh TL
复杂区域疼痛综合征是肢体创伤后出现的一种极其痛苦的病症。复杂的局部疼痛综合征表现出部分由针对毒蕈碱-2乙酰胆碱（M2）受体的自身抗体介导的自身免疫特征。 M2 受体参与复杂区域疼痛综合征的机制仍不清楚。基于我们最近的工作证明肢体神经创伤释放出一种有效的促痛、免疫显性的髓磷脂碱性蛋白片段，我们目前的序列数据库分析揭示了促痛的髓磷脂碱性蛋白片段与M2受体的意外且先前未描述的结构同源性。由于复杂区域疼痛综合征和促痛觉髓磷脂碱性蛋白活性在女性中普遍存在，这种髓磷脂碱性蛋白/M2同源性提出了一个诱人的假设，解释了自身免疫发病机制和性别二态性的机制，而性别二态性是发展复杂区域疼痛综合征和其他具有神经病理性特征的疼痛状态的脆弱性的基础。这一假设可能有助于开发针对慢性疼痛的新诊断和治疗策略。
Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic‐2 acetylcholine (M2) receptor. The mechanisms underlying the M2 receptor involvement in complex regional pain syndrome remain obscure. Based on our recent work demonstrating that limb nerve trauma releases a potent proalgesic, immunodominant myelin basic protein fragment, our present sequence database analyses reveal an unexpected and previously undescribed structural homology of the proalgesic myelin basic protein fragment with the M2 receptor. As both complex regional pain syndrome and the proalgesic myelin basic protein activity are prevalent in females, this myelin basic protein/M2 homology presents an inviting hypothesis explaining the mechanisms of autoimmune pathogenesis and sexual dimorphism that underlies vulnerability toward developing complex regional pain syndrome and other pain states with neuropathic features. This hypothesis may aid in the development of novel diagnostic and therapeutic strategies to chronic pain.
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影响因子：
9.3
作者：
Perera CJ;Duffy SS;Lees JG;Kim CF;Cameron B;Apostolopoulos V;Moalem-Taylor G
通讯作者：
Moalem-Taylor G
影响因子：
7.4
作者：
Guo TZ;Shi X;Li WW;Wei T;Clark JD;Kingery WS
通讯作者：
Kingery WS
DOI：
10.1016/j.bbi.2016.03.003
发表时间：
2016-08
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Ko JS;Eddinger KA;Angert M;Chernov AV;Dolkas J;Strongin AY;Yaksh TL;Shubayev VI
通讯作者：
Shubayev VI
影响因子：
3.6
作者：
de Rooij, Annetje M.;Perez, Roberto S. G. M.;Marinus, Johan
通讯作者：
Marinus, Johan
影响因子：
3.5
作者：
Kobayashi, Hideo;Chattopadhyay, Sharmila;Kato, Kinshi;Dolkas, Jennifer;Kikuchi, Shin-ichi;Myers, Robert R.;Shubayev, Veronica I.
通讯作者：
Shubayev, Veronica I.