ISOLATION OF NEW LYMPHOTROPIC RETROVIRUS FROM TWO SIBLINGS WITH HAEMOPHILIA B, ONE WITH AIDS
ISOLATION OF NEW LYMPHOTROPIC RETROVIRUS FROM TWO SIBLINGS WITH HAEMOPHILIA B, ONE WITH AIDS
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从两名 B 型血友病兄弟姐妹（其中一名患有艾滋病）中分离出新型淋巴细胞逆转录病毒
DOI：
10.1016/s0140-6736(84)91275-3
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Montagnier
中科院分区：
文献类型：
--
作者：
E. Vilmer;C. Rouzioux;F. Brun;A. Fischer;J. Chermann;F. Barre;C. Gazengel;C. Dauguet;P. Manigne;C. Griscelli;L. Montagnier
从两个患有血友病B的同胞的培养T淋巴细胞中分离出人嗜T淋巴细胞逆转录病毒。患者2是健康的，但患者1患有获得性免疫缺陷综合征。该逆转录病毒不同于人类T细胞白血病病毒（HTLV），但在形态和主要核心蛋白（P25）方面与淋巴结病相关逆转录病毒（LAV）相似。两名患者都有抗LAV和患者1的逆转录病毒抗体，通过酶联免疫吸附试验或放射免疫沉淀试验检测。血清流行病学数据表明该逆转录病毒通过血浆制品传播。
A human T-lymphotropic retrovirus was isolated from cultured T lymphocytes from two siblings with haemophilia B. Patient 2 was healthy, but patient 1 had acquired immunodeficiency syndrome. The retrovirus differed from human T-cell leukaemia virus (HTLV) but it was similar to the lymphadenopathy-associated retrovirus (LAV) in its morphology and its major core protein (P25). Both patients had antibodies against LAV and patient 1's retrovirus, detected by an enzyme-linked immunosorbent assay or a radioimmunoprecipitation assay. Seroepidemiological data indicated the transmission of this retrovirus by plasma products.