NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling
NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling
复制标题
NLRP3 通过减弱 cGAS-STING 信号传导保护小鼠免受辐射引起的结肠和皮肤损伤
DOI：
10.1016/j.taap.2021.115495
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发表时间：
2021-03-26
影响因子：
3.8
通讯作者：
Wang, Fang-Yu
中科院分区：
文献类型：
--
作者：
Wu, Tiancong;Gao, Jianhua;Wang, Fang-Yu
In the present study, the effects of NLRP3 on radiation-induced tissue damage, including colon and skin damage in mice, and the possible mechanisms were explored in vivo and in vitro. The mice were subjected to whole abdomen radiation by timed exposure to X-ray at a cumulative dose of 14 Gy. The survival rate showed that NLRP3 deficiency increased the mortality rate in mice. Furthermore, colon damage, evaluated by H&E staining and barrier function analysis, were significantly aggravated by NLRP3 deficiency. Enhanced phosphorylation of p-TBK1 and p-IRF3 in colonic tissue as well as elevated IFN-13 levels in the serum indicated hyperactivation of cGAS-STING signaling. Moreover, radiation-induced expression of p-TBK1, p-IRF3, and IFN-13 in BMDMs increased in vitro after NLRP3 knockout. Thus, our study outcomes suggest that NLRP3 may protect mice from radiation-induced tissue damage via attenuating cGAS-STING signaling.
