Nucleoside diphosphate kinase (Ndk): A pleiotropic effector manipulating bacterial virulence and adaptive responses.
Nucleoside diphosphate kinase (Ndk): A pleiotropic effector manipulating bacterial virulence and adaptive responses.
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DOI：
10.1016/j.micres.2017.09.001
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发表时间：
2017-12
影响因子：
6.7
通讯作者：
Hua Yu;X. Rao;Kebin Zhang
中科院分区：
文献类型：
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作者：
Hua Yu;X. Rao;Kebin Zhang
核苷二磷酸激酶是一种看家酶，它通过催化γ-磷酸从核苷三磷酸到核苷二磷酸的可逆转移来平衡细胞内的核苷三磷酸。除了在核苷酸代谢中的基础作用外，NDK还在蛋白质组氨酸磷酸化、DNA切割/修复和基因调控中发挥作用。最近的研究还表明，细菌分泌的NDK在调节毒力相关表型方面具有重要作用，包括群体感应调节、III型分泌系统激活和毒力因子的产生。此外，感染后，细菌释放的NDK参与调节宿主防御活动，如细胞凋亡、吞噬和炎症反应。鉴于NDK对细菌毒力和细菌-宿主相互作用具有多效性，细菌NDK在感染过程中的生物学意义是耐人寻味的。本文将简要介绍NDK的生物学特性及其在调节细菌毒力和适应中的作用，并将深入讨论NDK在细菌-宿主相互作用中的生物学意义。
Nucleoside diphosphate kinase (Ndk) is a housekeeping enzyme that balances cellular nucleoside triphosphate (NTP) pools by catalyzing the reversible transfer of γ-phosphate from NTPs to nucleoside diphosphates (NDPs). In addition to its fundamental role in nucleotide metabolism, Ndk has roles in protein histidine phosphorylation, DNA cleavage/repair, and gene regulation. Recent studies have also revealed that Ndk secreted from bacteria is important in modulating virulence-associated phenotypes including quorum sensing regulation, type III secretion system activation, and virulence factor production. Moreover, after infection, Ndks released from bacteria are involved in regulating host defense activities, such as cell apoptosis, phagocytosis, and inflammatory responses. Given that Ndk exerts a pleiotropic effect on bacterial virulence and bacteria-host interactions, the biological significance of the bacterial Ndks during infection is intriguing. This review will provide a synopsis of the current knowledge regarding the biological properties and roles of Ndks in regulating bacterial virulence and adaptation and will discuss in depth the biological significance of Ndk during bacteria-host interactions.