Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants.
Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants.
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DOI：
10.3390/nu13103604
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发表时间：
2021-10-14
期刊：
影响因子：
5.9
通讯作者：
Good M
中科院分区：
文献类型：
--
作者：
Nolan LS;Lewis AN;Gong Q;Sollome JJ;DeWitt ON;Williams RD;Good M
代谢组学在新生儿学中的应用提供了一种研究营养与婴儿健康之间复杂关系的方法。母乳代谢组的表征有助于研究影响新生儿代谢的营养物质，并确定针对有坏死性小肠结肠炎 (NEC) 等疾病风险的婴儿的饮食干预措施。在这项研究中，我们旨在确定 48 名早产儿 NEC 和非 NEC 健康对照母亲的母乳代谢组差异。 NEC 婴儿的母亲与健康对照婴儿的母亲之间的母乳代谢组存在最小显着差异。然而，当将母亲的乳汁与出生体重≤1.0公斤和>1.5公斤出生体重的对照婴儿进行比较时，发现与脂肪酸代谢、低聚糖、氨基糖、氨基酸、维生素和氧化应激相关代谢物相关的代谢组存在显着差异。了解母乳可能调节婴儿健康的功能生物学特征对于未来为早产儿提供量身定制的营养和护理非常重要。
The application of metabolomics in neonatology offers an approach to investigate the complex relationship between nutrition and infant health. Characterization of the metabolome of human milk enables an investigation into nutrients that affect the neonatal metabolism and identification of dietary interventions for infants at risk of diseases such as necrotizing enterocolitis (NEC). In this study, we aimed to identify differences in the metabolome of breast milk of 48 mothers with preterm infants with NEC and non-NEC healthy controls. A minimum significant difference was observed in the human milk metabolome between the mothers of infants with NEC and mothers of healthy control infants. However, significant differences in the metabolome related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins and oxidative stress-related metabolites were observed when comparing milk from mothers with control infants of ≤1.0 kg birth weight and >1.5 kg birth weight. Understanding the functional biological features of mothers’ milk that may modulate infant health is important in the future of tailored nutrition and care of the preterm newborn.