Ephs and Ephrins in malignant gliomas.
Ephs and Ephrins in malignant gliomas.
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DOI：
10.3109/08977194.2014.985787
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Debinski W
中科院分区：
文献类型：
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作者：
Ferluga S;Debinski W
Eph受体酪氨酸激酶和相应的ephrin配体在胶质瘤的发生和发展中起着关键作用。Eph受体和肝配蛋白的异常蛋白表达水平通常与较高的肿瘤分级和不良预后相关。它们在肿瘤发生中的功能是复杂的，这是由于相邻肿瘤细胞和肿瘤微环境之间可能共同发生的相互作用的复杂网络。Ephs和ephrin均定位于肿瘤细胞、肿瘤脉管系统、神经胶质瘤干细胞、浸润脑的肿瘤细胞和浸润肿瘤的免疫细胞的表面。它们可以促进和抑制致瘤性，这取决于所产生的下游正向和反向信号传导。所有上述特征使得Ephs/ephrins系统成为开发胶质瘤治疗新策略的有趣候选者。本文将对Ephs和ephrins的结构和功能进行综述，特别强调它们在恶性胶质瘤中的作用。
Eph receptor tyrosine kinases and the corresponding ephrin ligands play a pivotal role in glioma development and progression. Aberrant protein expression levels of the Eph receptors and ephrins are often associated with higher tumor grade and poor prognosis. Their function in tumorigenesis is complex due to the intricate network of possible co-occurring interactions between neighboring tumor cells and tumor microenvironment. Both Ephs and ephrins localize on the surface of tumor cells, tumor vasculature, glioma stem cells tumor cells infiltrating brain and immune cells infiltrating tumors. They can both promote and inhibit tumorigenicity depending on the downstream forward and reverse signalling generated. All the above-mentioned features make the Ephs/ephrins system an intriguing candidate for the development of new therapeutic strategies in glioma treatment. This review will give a general overview on structure and function of Ephs and ephrins, with particular emphasis on the state-of-the-knowledge of their role in malignant gliomas.