EMBRYOLOGY OF EXOMPHALOS AND ALLIED MALFORMATIONS
EMBRYOLOGY OF EXOMPHALOS AND ALLIED MALFORMATIONS
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DOI：
10.1136/adc.38.198.142
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发表时间：
1963-01-01
影响因子：
5.2
通讯作者：
DUHAMEL, B
中科院分区：
文献类型：
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作者：
DUHAMEL, B
真正的先天性畸形，也就是说，那些由胚胎发育缺陷而不是胎儿疾病引起的畸形，是巨大畸形的较小形式，它们通过一系列连续的中间形式与巨大畸形相关联。正常的胚胎学解释了畸形和畸形;解剖学研究和畸形的实验性创造使我们能够更好地理解某些胚胎发生机制。这些概念被脑脊髓发育不良所承认（Giroud，Martinet和Soleres，1958）和头端畸形，我已经证明它们对尾端畸形也有效（D，uhamel，1961）。外胚层属于腹面壁畸形的一组，其由胚胎身体关闭的重要机制的干扰引起。在最初的分割和原肠胚形成阶段之后，原始胚胎类似于一个扁平的椭圆形圆盘（胚盘），其背层（外胚层）与羊膜囊壁连续;腹层（内胚层）与卵黄囊壁连续（图11和12）。1A和2A）。
True congenitalmalformations, that is to say, those resulting from a defect of the embryonic development and not from a foetal disease, are minor forms of the great monstrosities to which they are related by a continuous series of intermediary forms. Normal embryology explains monstrosities and thus malformations; anatomic study and the experi-mental creation of monstrosities allow a better understanding of certain embryogenetic mechanisms.These notions are admitted for the encephalomyelo-dysplasias (Giroud, Martinet and Soleres, 1958), and for malformations of the cephalic extremity, andI have shown that they are also valid for malformations of the caudal extremity (D, uhamel, 1961). Exomphalos belongs to the group of ventral wall malformations that result from a disturbance of the vital mechanism of closing of the body of the embryo. After the initial segmentation and gastrulation stages, the primitive embryo resembles a flat, oval disk (the germinal disk), the dorsal layer of which, the ectoblast, is continuous with the wall of the amniotic vesicle; the ventral layer, the entoblast, is continuous with the wall of the yolk sac (Figs. 1A and 2A).