Effect of Daily Intake of Lactobacillus casei on Microbial Diversity and Dynamics in a Healthy Pediatric Population
Effect of Daily Intake of Lactobacillus casei on Microbial Diversity and Dynamics in a Healthy Pediatric Population
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DOI：
10.1007/s00284-019-01713-9
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发表时间：
2019-09-01
影响因子：
2.6
通讯作者：
de Meij, Tim G. J.
中科院分区：
文献类型：
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作者：
el Hassani, Sofia el Manouni;de Boer, Nanne K. H.;de Meij, Tim G. J.
新出现的证据表明，肠道微生物群的改变是多种疾病病理生理学的关键因素。因此，越来越多地评估了针对微生物的干预措施，包括益生菌的管理。益生菌如何有助于体内平衡或逆转生态失调的机制仍有待阐明。在本研究中，我们评估了12- 18岁健康儿童每日摄入干酪乳杆菌菌株Shirota（LcS）对肠道微生物群组成多样性和稳定性的影响。结果与未接触LcS的健康儿童进行了比较。在为期6周的时间内，两组每周收集粪便样本。共纳入18名儿童（6名益生菌; 12名非益生菌）。在1周的时间间隔，没有差异的多样性和稳定性，观察暴露于LcS与对照组的儿童。健康儿童摄入LcS不会导致更多样化和稳定的肠道微生物群组成。应在儿童中进行大型双盲安慰剂对照随机临床试验，以更深入地了解潜在的有益健康后果。
Emerging evidence exists that an altered gut microbiota is a key factor in the pathophysiology of a variety of diseases. Consequently, microbiota-targeted interventions, including administration of probiotics, have increasingly been evaluated. Mechanisms on how probiotics contribute to homeostasis or reverse (effects of) dysbiosis remain yet to be elucidated. In the current study, we assessed the effects of daily Lactobacillus casei strain Shirota (LcS) ingestion in healthy children aged from 12-18years on gut microbiota compositional diversity and stability. Results were compared to healthy children without LcS exposure. For a period of 6weeks, fecal samples were collected weekly by both groups. In total, 18 children were included (6 probiotics; 12 non-probiotics). At 1-week intervals, no differences in diversity and stability were observed in children exposed to LcS versus controls. LcS ingestion by healthy children does not result in a more diverse and stable gut microbiota composition. Large double-blind placebo-controlled randomized clinical trials in children should be performed to gain more insight on potential beneficial health consequences.