Rates of and risk factors for trabecular and cortical BMD loss in middle-aged and elderly African-ancestry men.
Rates of and risk factors for trabecular and cortical BMD loss in middle-aged and elderly African-ancestry men.
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中老年非洲裔男性小梁骨和皮质 BMD 损失的比率和危险因素。
DOI：
10.1002/jbmr.2359
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Zmuda,JosephM
中科院分区：
文献类型：
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作者：
Sheu,Yahtyng;Bunker,ClareannH;Jonnalagadda,Pallavi;Cvejkus,RyanK;Patrick,AlanL;Wheeler,VictorW;Gordon,ChristopherL;Zmuda,JosephM
低骨小梁（Tb）和皮质（Ct）体积BMD（vBMD）与骨折风险增加有关，但对Tb和Ct vBMD损失与衰老的模式和相关性知之甚少。我们检查了桡骨和胫骨的总骨密度、Tb.vBMD和Ct.vBMD的变化率，并确定了1569名40岁及以上非洲裔男性vBMD丢失的相关因素。间隔6年使用定量计算机断层扫描测量vBMD。桡骨的Tb.vBMD年丢失率显著（-0.047%/年，p= 0.016），但胫骨不显著。在桡骨处，在40至49岁的男性中观察到Tb.vBMD的显著损失，其在老年男性中似乎是衰减的并且没有统计学显著性。相反，两个骨骼部位的Ct.vBMD下降相似（-0.254至-0.264%/年，p< 0.0001），并且在所有年龄组中一致。vBMD变化与体重（除桡骨Ct.vBMD外）和糖尿病（仅Ct.vBMD）呈正相关，而与高血压（除桡骨Tb.vBMD外）、吸烟（仅Ct.vBMD）和雄激素剥夺治疗（仅皮质vBMD）呈负相关。骨小梁和皮质vBMD丢失似乎遵循非洲血统的中老年男性的不同模式。与vBMD下降相关的因素也因室和解剖部位而异。需要进一步的研究来更好地了解非洲血统男性早期BMD丢失的生理机制。© 2014美国骨与矿物质研究学会。
Low trabecular (Tb) and cortical (Ct) volumetric BMD (vBMD) are related to increased fracture risk, but little is known about the patterns and correlates of Tb and Ct vBMD loss with aging. We examined the rates of change in total, Tb.vBMD, and Ct.vBMD at the radius and tibia, and identified factors associated with vBMD loss among 1569 men of African descent aged 40 years and older. Quantitative computed tomography was used to measure vBMD 6 years apart. The annualized rate of loss in Tb.vBMD was significant at the radius (–0.047%/yr,p= 0.016) but not at the tibia. At the radius, a significant loss of Tb.vBMD was observed in men aged 40 to 49 years that appeared to be attenuated and not statistically significant among older age men. In contrast, the decline in Ct.vBMD was similar at both skeletal sites (–0.254 to –0.264%/yr,p< 0.0001) and was consistent across all age groups. Positive associations were found for vBMD changes with body weight (all but radius Ct.vBMD) and diabetes (Ct.vBMD only), whereas negative associations were found with hypertension (all but radius Tb.vBMD), smoking (Ct.vBMD only), and androgen deprivation therapy (cortical vBMD only). Trabecular and cortical vBMD loss appears to follow different patterns among middle‐ and older‐aged men of African ancestry. Factors associated with the decline in vBMD also varied by compartment and anatomical site. Additional studies are needed to better understand the physiological mechanisms underlying early BMD loss among African‐ancestry men. © 2014 American Society for Bone and Mineral Research.