Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation
Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation
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DOI：
10.1212/01.wnl.0000247277.81400.43
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发表时间：
2006-12-12
期刊：
影响因子：
9.9
通讯作者：
Johnson, S. C.
中科院分区：
文献类型：
--
作者：
Gleason, C. E.;Schmitz, T. W.;Johnson, S. C.
我们将 9 名未接受过激素治疗 (HT) 的女性的功能磁共振成像和认知数据与暴露于相反结合马雌激素 (CEE) (n = 10) 或相反雌二醇 (n = 4) 的女性的数据进行了比较。暴露于任何一种形式的 HT 都与更健康的功能磁共振成像反应相关。然而，接触过 CEE 的女性比未接触过 HT 或接触过雌二醇的受试者表现出较差的记忆力。这些初步发现强调需要表征各种 HT 的差异神经效应。
We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.