Function and regulation of osteopontin in response to mechanical stress
Function and regulation of osteopontin in response to mechanical stress
复制标题
DOI：
10.1359/jbmr.060315
复制
发表时间：
2006-06-01
影响因子：
6.2
通讯作者：
Moriyama, Keiji
中科院分区：
文献类型：
--
作者：
Fujihara, Shinji;Yokozeki, Masahiko;Moriyama, Keiji
广泛的组织学研究揭示了OPN敲除小鼠牙齿运动系统中机械应力引起的骨重塑损伤。对转基因小鼠OPN启动子的分析显示，机械应力响应元件位于上游5.5 kb区域。这些结果在原代培养细胞中也得到了。
Extensive histological study revealed the impairment of bone remodeling caused by mechanical stress in OPN knockout mice in a tooth movement system. Analysis of OPN promoter transgenic mice showed the mechanical stress response element(s) in the 5.5-kb upstream region. These results were also obtained with the primary cultured cells.