Cannabinoid receptor 1 (CNR1) gene:: Impact on antidepressant treatment response and emotion processing in Major Depression
Cannabinoid receptor 1 (CNR1) gene:: Impact on antidepressant treatment response and emotion processing in Major Depression
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DOI：
10.1016/j.euroneuro.2008.05.003
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发表时间：
2008-10-01
影响因子：
5.6
通讯作者：
Baune, Bernhard T.
中科院分区：
文献类型：
--
作者：
Domschke, Katharina;Danniowski, Udo;Baune, Bernhard T.
内源性大麻素系统参与了抑郁症和焦虑症的发病机制、抗抑郁药物在动物模型中的作用以及健康志愿者情绪处理的神经生物学过程，因此，在256例白人抑郁症患者中评估了大麻素受体1基因（CNR1）变体rs1049353和rs12720071对抗抑郁治疗反应的影响。33名抑郁症患者的子样本在情绪面孔的视觉呈现下进行fMRI扫描，CNR1 rs1049353 G等位基因增加了抗抑郁药治疗抵抗的风险，特别是在高共病焦虑的女性患者中。CNR1 rs1049353 G等位基因携带者也表现出较弱的双边杏仁核，壳核和苍白球的活动，以及左偏侧尾状核和丘脑的活动，在蒙面的快乐faces.This分析提供了初步的支持CNR1基因变异的作用，抑郁和焦虑，可能介导的皮层下低反应社会奖励刺激。(C)2008 Elsevier B.V.和ECNP。All rights reserved.
The endocannabinoid system has been implicated in the pathogenesis of depression and anxiety, the mediation of antidepressant drug effects in animal models and the neurobiology of emotion processing in healthy volunteers.Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression. A subsample of 33 depressed patients was additionally scanned by fMRI under visual presentation of emotional faces.The CNR1 rs1049353 G allele conferred an increased risk of antidepressant treatment resistance, particularly in female patients with high comorbid anxiety. CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces.This analysis provides preliminary support for a role of CNR1 gene variation in depression and anxiety, potentially mediated by subcortical hypo-responsiveness to social reward stimuli. (C) 2008 Elsevier B.V. and ECNP. All rights reserved.