Improvement in the accuracy of dual energy X-ray absorptiometry for whole body and regional analysis of body composition: Validation using piglets and methodologic considerations in infants
Improvement in the accuracy of dual energy X-ray absorptiometry for whole body and regional analysis of body composition: Validation using piglets and methodologic considerations in infants
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DOI：
10.1203/00006450-199704000-00022
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发表时间：
1997-04-01
影响因子：
3.6
通讯作者：
Atkinson, SA
中科院分区：
文献类型：
--
作者：
Brunton, JA;Weiler, HA;Atkinson, SA
此前，我们对仔猪进行了双能x射线吸收仪（DXA） （Hologic QDR-1000/W）扫描和胴体分析，以评估儿科全身软件（PedWB） （V5.35）在婴儿中的应用。为婴儿全身（InfWB） （V5.56）设计的软件升级导致DXA的重新评估：1)使用InfWB软件重新分析原始扫描，2)将InfWB估计的骨矿物质含量（BMC）和瘦脂肪量与化学分析进行比较。其他评估包括1)区域分析方法和2)扫描场中的伪影和婴儿桌垫。小仔猪（n = 10，体重1575 +/- 73 g）和大仔猪（n = 10，体重5894 +/- 208 g）的InfWB全身测量的平均变异系数小于2.6%，但脂肪量高于PedWB（分别为8.0%比6.3%和6.6%比3.5%）。在大型仔猪中，InfWB对BMC、瘦肉和脂肪质量有很好的估计。在小仔猪中，InfWB的脂肪量与化学分析相关，而与PedWB无关。使用InfWB对BMC的估计有改善，从27 +/- 2.2 g提高到32 +/- 2.3 g（胴体灰分= 38 +/- 3.3 g）。与化学分析相比，InfWB的股骨BMC分析是精确的。DXA扫描区域的伪影（尿布和毯子）导致DXA估计的脂肪和瘦肉块增加。婴儿桌垫使仔猪的脂肪量估计增加了50%，因此在常规使用之前需要进一步研究。如果仔细执行扫描程序，DXA技术的改进可以产生更精确的工具。
Previously, we conducted dual energy x-ray absorptiometry (DXA) (Hologic QDR-1000/W) scans and carcass analysis of piglets to evaluate the Pediatric Whole Body software (PedWB) (V5.35) for use in infants. A software upgrade designed for infant whole body (InfWB) (V5.56) led to a reassesment of DXA by: 1) reanalysis of the original scans using InfWB software and 2) comparison of InfWB-estimates of bone mineral content (BMC) and lean and fat mass with chemical analysis. Other assessments included 1) methods of regional analysis and 2) artifacts and the Infant Table Pad in the scan field. The mean coefficients of variation for InfWB whole body measures in small piglets (n = 10, weight 1575 +/- 73 g) and large piglets (n = 10, weight 5894 +/- 208 g) were less than 2.6% except for fat mass which was higher (8.0% versus 6.3% and 6.6% versus 3.5%, respectively) compared with PedWB. In large piglets InfWB produced good estimates of BMC, lean and fat masses. In small piglets, fat mass by InfWB was correlated with chemical analysis, but not by PedWB. There was improvement in the estimation of BMC with InfWB, from 27 +/- 2.2 g to 32 +/- 2.3 g (carcass ash = 38 +/- 3.3 g). Femur BMC analysis by InfWB was precise and was accurate when compared with chemical analysis. Artifacts in the DXA scan field (diapers and blankets) resulted in an increase of the DXA-estimated fat and lean masses. The Infant Table Pad increased the estimate of fat mass in a small piglet by 50%, thus further study is required before it is used routinely. Improvements of the DXA technology have resulted in a more accurate tool, if scanning procedures are carefully implemented.