Eosinophilia in the diagnosis of atheroembolic renal disease.
Eosinophilia in the diagnosis of atheroembolic renal disease.
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嗜酸性粒细胞增多症在动脉粥样硬化性肾病的诊断中的应用。
DOI：
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发表时间：
1987
影响因子：
4.2
通讯作者：
E. Lewis
中科院分区：
文献类型：
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作者：
B. Kasinath;H. Corwin;A. Bidani;S. Korbet;M. Schwartz;E. Lewis
我们报告了 6 名患有嗜酸性粒细胞增多和动脉粥样硬化性肾病的患者。肾脏或皮肤活检的组织学检查显示脉管系统中存在广泛的动脉粥样硬化栓塞。然而，没有观察到血管或肾小管间质炎症的证据。嗜酸性粒细胞计数范围为 540 至 2,000 个细胞/mm3。查阅文献后发现，80%（36 名中的 29 名）有充分报告的白细胞总数和分类白细胞计数的患者患有与动脉粥样硬化性疾病相关的嗜酸粒细胞增多症。相比之下，对 18 个月内连续 40 名急性肾衰竭患者的临床记录进行审查后，仅发现 1 例嗜酸粒细胞增多症 (2.5%)。后一位患者被确定患有急性间质性肾炎。因此，嗜酸性粒细胞增多似乎是动脉粥样硬化性肾病存在的有用诊断线索。
We report 6 patients with eosinophilia and atheroembolic renal disease. Histologic examination of biopsy of kidney or skin revealed extensive atheroembolic in the vasculature. However, no evidence of vascular or tubulointerstitial inflammation was observed. Eosinophil count ranged from 540 to 2,000 cells/mm3. Upon review of the literature, 80% (29 out of 36) of patients with adequately reported total and differential leukocyte counts had eosinophilia in association with atheroembolic disease. In contrast, review of the clinical records of 40 consecutive patients with acute renal failure seen during an 18-month period uncovered only 1 case of eosinophilia (2.5%). This latter patient was established as having acute interstitial nephritis. Thus eosinophilia appears to be a helpful diagnostic clue to the presence of atheroembolic renal disease.