Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
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HTLV-II x 和腺病毒 E1A 蛋白在转录激活中的功能关系。
DOI：
10.1126/science.2996140
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Gaynor,RB
中科院分区：
文献类型：
--
作者：
Chen,IS;Cann,AJ;Shah,NP;Gaynor,RB
人类T细胞白血病病毒（HTLV）的细胞转化机制被认为涉及一种新的基因，称为xG。该基因是HTLV复制所必需的，并通过增强HTLV长末端重复序列的转录而起作用。HTLVx基因产物也可能引起正常细胞基因的异常转录，导致感染细胞的转化。虽然还没有证据表明这种机制，但已经表明HTLV-IIx基因产物可以激活腺病毒E1 A依赖性早期启动子的转录，因此具有激活细胞基因的潜力。研究还表明，腺病毒和疱疹伪狂犬病立即早期蛋白激活HTLV-I和HTLV-II长末端重复序列的表达，尽管水平低于外源基因产物。这些发现表明不同病毒的转录调控基因可能具有共同的作用机制。
The mechanism of cellular transformation by the human T-cell leukemia viruses (HTLV) is thought to involve a novel gene known as thexgene. This gene is essential for HTLV replication and acts by enhancing transcription from the HTLV long terminal repeat. The HTLVxgene product may also cause aberrant transcription of normal cellular genes, resulting in transformation of the infected cells. Although there is no evidence as yet for such a mechanism, it was shown that the HTLV-IIxgene product can activate transcription from adenovirus E1A-dependent early promoters and therefore has the potential to activate cellular genes. It was also shown that the adenovirus and herpes pseudorabies immediate early proteins activate expression from the HTLV-I and HTLV-II long terminal repeats, though at lower levels than with thexgene product. These findings indicate possible common mechanisms of action for transcription-regulatory genes of distinct viruses.