A case-control study of the environmental risk factors for narcolepsy
A case-control study of the environmental risk factors for narcolepsy
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DOI：
10.1159/000111581
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发表时间：
2007-01-01
影响因子：
5.7
通讯作者：
Harsh, John R.
中科院分区：
文献类型：
--
作者：
Picchioni, Dante;Hope, Chris R.;Harsh, John R.
背景：尽管人们公认环境危险因素在发作性睡病病因学中的重要性，但对此主题的研究很少。这项研究试图填补文献中的这一空白，并通过病例对照研究评估压力源和传染病的风险。方法：病例 (n = 63) 是通过斯坦福发作性睡病中心招募的。所有患者均为 HLA-DQB1*0602 阳性，符合传统的多次睡眠潜伏期测试标准，并报告明确的猝倒。对照 (n = 63) 是病例的非亲属家庭成员和当地社区成员。使用自填问卷来评估可能的风险因素的频率和时间。结果：在检查的传染病中，只有流感感染和不明原因的发烧具有显着风险。一些压力源会带来重大风险，包括睡眠习惯的重大改变。当考虑到所有危险因素的发生时间时，青春期前的暴露会增加发生发作性睡病的风险。结论：这些发现强调了环境危险因素在发作性睡病病因学中的重要性。这凸显了对发作性睡病这一方面进行进一步研究的必要性，以便能够全面了解这种影响两千分之一个体的疾病。版权所有 (c) 2007 S. Karger AG，巴塞尔。
Background: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. This study sought to fill this gap in the literature and assess the risk of stressors and infectious diseases using a case-control study. Methods: Cases (n = 63) were recruited through the Stanford Center for Narcolepsy. All were HLA-DQB1*0602 positive, met conventional Multiple Sleep Latency Test criteria, and reported unambiguous cataplexy. Controls (n = 63) were nonrelated family members of cases and local community members. A self-administered questionnaire was used to assess the frequency and timing of possible risk factors. Results: Of the infectious diseases examined, only flu infections and unexplained fevers carried a significant risk. Several of the stressors carried a significant risk including a major change in sleeping habits. When the timing of all risk factors was considered, exposure prior to puberty increased the risk for developing narcolepsy. Conclusions: These findings emphasize the importance of environmental risk factors in the etiology of narcolepsy. This highlights the need for further research on this aspect of narcolepsy so a complete understanding of a disorder that affects 1 in 2,000 individuals can emerge. Copyright (c) 2007 S. Karger AG, Basel.