Posterior reversible encephalopathy syndrome in a child with bronchial asthma
Posterior reversible encephalopathy syndrome in a child with bronchial asthma
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DOI：
10.1016/j.braindev.2006.02.008
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发表时间：
2006-09-01
影响因子：
1.7
通讯作者：
Watabane, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Kurahashi, Hirokazu;Okumura, Akihisa;Watabane, Kazuyoshi
虽然后可逆性脑病综合征（PRES）是由多种疾病引起的，但尚未见PRES与支气管哮喘相关的报道。我们报告一例在治疗严重哮喘发作时出现PRES的病例。一名4岁女孩因哮喘发作使用类固醇治疗。从住院第10天开始，观察到高血压、肺水肿和心脏肿大。尽管给予速尿治疗，但在住院第23天，她变得昏睡，并出现全身抽搐。CT显示双侧枕白质低密度区，住院第28天MRI显示t2加权和FLAIR图像相同区域的高强度区。停用皮质类固醇及进一步降压治疗后，患者意识有所改善。住院第67天MRI未见异常，2年后未见神经系统后遗症。我们应该意识到PRES是与类固醇治疗相关的罕见但重要的不良事件，因为高血压和水潴留是类固醇的主要不良反应。(c) 2006 Elsevier B.V.版权所有
Although posterior reversible encephalopathy syndrome (PRES) is caused by various conditions, there have been no reports on PRES associated with bronchial asthma. We report a case with PRES during the treatment for severe asthmatic attack. A 4-year-old girl was treated for asthmatic attack with steroids. From the 10th hospital day, hypertension, pulmonary edema, and cardiomegaly were observed. In spite of treatment with furosemide, she became lethargic and had a generalized convulsion on the 23rd hospital day. CT showed low density areas in the bilateral occipital white matter and MRI on the 28th hospital day demonstrated high intensity areas in the same regions on T2-weighted and FLAIR images. After discontinuation of corticosteroid and further antihypertensive therapy, her consciousness improved. MRI on the 67th hospital day had no abnormalities and Do neurological sequelae were seen at 2 years after the event. We should be aware that PRES is a rare but important adverse event related to steroid therapy, because hypertension and water retention are major adverse effects of steroids. (c) 2006 Elsevier B.V. All rights reserved.