Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNγ-mediated B cell depletion
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNγ-mediated B cell depletion
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DOI：
10.1016/s1074-7613(01)00236-9
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发表时间：
2001-11-01
期刊：
影响因子：
32.4
通讯作者：
van Lier, RAW
中科院分区：
文献类型：
--
作者：
Arens, R;Tesselaar, K;van Lier, RAW
肿瘤坏死因子受体家族成员CD27与其配体CD70的相互作用为T细胞的扩增提供了共刺激信号。正常情况下，CD70的严格调控表达确保了这种共刺激信号的瞬时可获得性。在B细胞上表达构成CD70的小鼠外周T细胞数量较高，显示出向效应型T细胞分化的增加。CD70转基因(TG)小鼠初级和次级淋巴器官中B细胞数量进行性减少。这种B细胞耗竭是由CD27诱导T细胞产生干扰素-γ引起的。我们的结论是，除了在控制激活的T细胞池的大小方面发挥作用外，CD27的结扎还通过促进效应器T细胞的分化而促进免疫。
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFN gamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.