Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm
Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm
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血管内皮损伤中的肾上腺髓质素和联合治疗：新范式的时候了。
DOI：
10.2174/1570161112666141014145735
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发表时间：
2015-01-01
影响因子：
4.5
通讯作者：
Ren, Jun
中科院分区：
文献类型：
--
作者：
Yuan, Ming;Wang, Qiurong;Ren, Jun
肾上腺髓质素是一种高度保守的血管活性多肽，参与多种生理和病理生理过程，包括妊娠、胚胎发育、肿瘤进展和血管张力调节。具体地说，肾上腺髓质素的表达广泛分布于心血管系统，包括心脏、肺、血管和肾脏。肾上腺髓质素与其受体共定位的观察表明，肾上腺髓质素可能作为一种自分泌和/或旁分泌因子参与心血管功能的调节。在这篇综述中，我们描述了与血管内皮细胞功能相关的血浆和局部肾上腺髓质素的病理生理变化及其相关的信号机制。最近的证据表明，肾上腺髓质素在调节血管内皮功能方面具有独特的作用，部分是通过调节cAMP、cGMP和细胞内钙动员来实现的。本文综述了肾上腺髓质素在生理和病理生理条件下的血管内皮细胞作用，以期为肾上腺髓质素在血管疾病中的临床应用提供指导。
Adrenomedullin is a highly conserved vasoactive peptide participating in a variety of physiological and pathophysiological processes including pregnancy, embryonic development, tumor progression and regulation of vascular tone. In particular, adrenomedullin expression is widely distributed throughout the cardiovascular system including heart, lungs, blood vessels and kidneys. The observation that adrenomedullin co-localizes with its receptors suggests that the peptide may act as an autocrine and/or paracrine factor in the regulation of cardiovascular function. In this review, we described the pathophysiological changes in plasma and local adrenomedullin associated with vascular endothelial function and the signaling mechanisms involved. Recent evidence has depicted a unique role of adrenomedullin in the regulation of vascular endothelial function in part through regulation of cAMP, cGMP and intracellular Ca(2+) mobilization. This review summarized vascular endothelial actions of adrenomedullin under both physiological and pathophysiological conditions in an effort to provide guidance for the clinical application of adrenomedullin in vascular diseases.