Normal hematological and plasma biochemical parameters of the captive bonnet monkey (Macaca radiata)
Normal hematological and plasma biochemical parameters of the captive bonnet monkey (Macaca radiata)
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DOI：
10.1007/bf02557725
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发表时间：
1998-04-01
期刊：
影响因子：
1.7
通讯作者：
Shetty, KT
中科院分区：
文献类型：
--
作者：
Ramachandra, SG;Ramesh, V;Shetty, KT
帽猴越来越多地被用作生物医学研究的模型。然而，与恒河猴不同，关于血浆的血液学和生化特征的信息非常少。比较恒河猴和人的血浆生化参数数据对于利用该物种进行生物医学研究是必不可少的。在两种性别的幼年和成年帽猴组中，努力测定选定的血清酶、葡萄糖、甘油三酯、血尿素氮、肌酐、总蛋白、白蛋白、胆固醇、胆红素、钙、磷、钠、镁、钾和总红细胞计数、总白细胞计数、血红蛋白、PCV、ESR和白细胞分类计数。除碱性磷酸酶外，猴的所有参数值均与恒河猴和人相似。与恒河猴和人类中观察到的浓度相比，碱性磷酸酶的值高出3-5倍。调查还描述了成年人和青少年之间以及两性之间的差异。这些数据对于科学家使用这种猴子作为人类替代模型是有价值的。
The bonnet monkey is being increasingly used as a model in biomedical research. However, unlike the rhesus monkey, very little information on the hematological and biochemical characteristics of blood plasma is available. Comparative data on plasma biochemical parameters vis-a-vis rhesus and human is essential for utilization of this species in biomedical research. Efforts were made to determine selected serum enzymes, glucose, triglycerides, blood urea nitrogen, creatinine, total protein, albumin, cholesterol, bilirubin, calcium, phosphorus, sodium, magnessium, potassium and total erythrocyte count, total leukocyte count, hemoglobin, PCV, ESR, and differential leukocyte count in groups of juvenile and adult bonnet monkeys of both sexes. The monkeys exhibited similar values for all the parameters in comparison to rhesus and human except for alkaline phosphatase. The value for alkaline phosphatase was 3-5 fold higher when compared to concentrations seen in rhesus monkeys and human beings. The investigation also describes the variations seen between adults and juveniles, as well as between the sexes. The data presented is valuable for scientists using this species of monkey as a human surrogate model.