Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes
Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes
复制标题
DOI：
10.1111/j.2040-1124.2010.00059.x
复制
发表时间：
2010-12-01
影响因子：
3.2
通讯作者：
Hanafusa, Toshiaki
中科院分区：
文献类型：
--
作者：
Shibasaki, Saeko;Imagawa, Akihisa;Hanafusa, Toshiaki
暴发性1型糖尿病的特征是β细胞几乎完全破坏，导致胰岛素分泌不足。在本研究中，我们的目的是澄清相关的临床特征，血清C肽水平测定的高灵敏度的方法，荧光酶免疫法，在12例暴发型1型糖尿病患者。血清C肽在4例患者中检测到（0.007-0.10 nmol/L），8例患者未检测到。血清C肽水平与胰岛素日剂量呈负相关（P < 0.01）。可检测到C肽的患者的M值显著低于未检测到C肽的患者（P = 0.01）。总之，我们目前的研究结果表明，即使是非常低水平的内源性胰岛素分泌能力可以提高每日胰岛素剂量和稳定血糖水平。（J Diabetes Invest，doi：10.1111/j.2040-1124.2010.00059.x，2010）
Fulminant type 1 diabetes is characterized by almost complete beta-cell destruction, resulting in scarce insulin secretion. In the present study, we aimed to clarify clinical features related to serum C-peptide levels measured by a high sensitivity method, chemiluminescent enzyme immunoassay, in 12 patients with fulminant type 1 diabetes. Serum C-peptide was detected (0.007-0.10 nmol/L) in four patients and was not detected in eight patients. A negative correlation was observed between serum C-peptide levels and daily dosages of insulin (P < 0.01). The patients with detectable C-peptide showed a significantly lower M-value than those without (P = 0.01). In conclusion, our present results suggest that even very low levels of endogenous insulin secreting capacity can improve daily dosages of insulin and stabilize blood glucose levels. (J Diabetes Invest, doi:10.1111/j.2040-1124.2010.00059.x, 2010)