BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders
BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders
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DOI：
10.1007/s00787-013-0495-6
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发表时间：
2014-08-01
影响因子：
6.4
通讯作者：
Gervasini, Guillermo
中科院分区：
文献类型：
--
作者：
Gamero-Villarroel, Carmen;Gordillo, Inmaculada;Gervasini, Guillermo
脑源性神经营养因子(BDNF)基因可能会影响饮食行为、体重和认知障碍。我们的目的是研究BDNF基因变异是否可能影响神经性厌食症或暴食症(AN，BN)患者的人体测量学和心理参数，并/或调节这种疾病的风险。对169例无血缘关系的女性患者和312例健康对照进行了两个常见的BDNF单核苷酸多态(SNPs)-Val66Met和C-270T的基因分型，以及几个选定的Tag-SNPs。采用EDI-2和SCL-90R评定相关人格特征和精神病理症状。没有单个SNP或单倍型在AN或BN的风险中起到相关作用。在BN组中，rs16917237 TT型与体重(74.63+/-A16.58 vs.57.93+/-A13.02)和体重指数(28.94+/-A6.22 vs.22.23+/-A4.77)显著相关。使用滑动窗口方法对三个相邻的SNP进行单倍型分析，产生了四个感兴趣的基因座。基因座3(rs10835210/rs16917237/C-270T)对测量的精神病理症状有广泛的影响。在AN和BN患者中，该基因的单倍型CGC和CGT与SCL-90R量表的所有三个量表的得分相关。相比之下，EDI-2库存的结果基本上没有受到影响。这些初步结果表明，BDNF基因位点的变异可能有助于人体测量特征和精神病理症状，这些症状是ED患者常见的，但不是唯一的。
The brain-derived neurotrophic factor (BDNF) gene may influence eating behavior, body weight and cognitive impairments. We aimed to investigate whether BDNF genetic variability may affect anthropometric and psychological parameters in patients with anorexia or bulimia nervosa (AN, BN) and/or modulate the risk for the disorder. A total of 169 unrelated female patients and 312 healthy controls were genotyped for two common BDNF single-nucleotide polymorphisms (SNPs), Val66Met and C-270T, and several selected tag-SNPs. Associated personality characteristics and psychopathological symptoms were assessed by the EDI-2 and SCL-90R inventories, respectively. No single SNP or haplotype played a relevant role in the risk for AN or BN. The rs16917237 TT genotype was significantly associated with increased weight (74.63 +/- A 16.58 vs. 57.93 +/- A 13.02) and body mass index (28.94 +/- A 6.22 vs. 22.23 +/- A 4.77) in the BN group after correcting for multiple testing. Haplotype analyses using a sliding window approach with three adjacent SNPs produced four loci of interest. Locus 3 (rs10835210/rs16917237/C-270T) showed a broad impact on the measured psychopathological symptoms. Haplotypes CGC and CGT in this locus correlated with scores in all three scales of the SCL-90R inventory, both in AN and BN patients. In contrast, the results of the EDI-2 inventory were largely unaffected. These preliminary results suggest that variability in the BDNF gene locus may contribute to anthropometric characteristics and also psychopathological symptoms that are common but not exclusive of ED patients.