Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury
Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury
复制标题
利用 AIE 荧光探针实时观察心肌缺血再灌注损伤过程中 HOBr 的波动
DOI：
10.1039/d2cc06140f
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发表时间：
2022
影响因子：
4.9
通讯作者：
Bo Tang
中科院分区：
文献类型：
--
作者：
Jian Zhang;Yingying Xie;Jushuai Ma;kaiqiang Liu;Yunshu Ding;Yong Li;Xiaoyun Jiao;Xilei Xie;Xu Wang;Bo Tang
研制了两种具有AIE特性的荧光探针QM-S和QM-Se。这些探针显示MIRI时心肌细胞内次溴酸（HOBr）增加。还观察到MIRI可能通过对抗氧化应激以及抑制炎症和铁凋亡来减轻，这可以介导氧化应激。
Two fluorescent probes (QM-S and QM-Se) featuring AIE properties were developed. The increased intracellular hypobromous acid (HOBr) in cardiomyocytes during MIRI was revealed with these probes. It was also observed that MIRI might be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which could mediate oxidative stress.