On the Biocatalytic Synthesis of Silicone Polymers
On the Biocatalytic Synthesis of Silicone Polymers
复制标题
有机硅聚合物的生物催化合成
DOI：
10.1039/d4fd00003j
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发表时间：
2024
影响因子：
3.4
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Lu Y
聚硅氧烷，其中聚（二甲基）硅氧烷（PDMS）是最常见的实例，由于其Si-O-Si主链结构赋予的物理化学性质，其广泛用于各种工业和消费应用中。PDMS的常规合成涉及二甲基二氯硅烷的水解，这由于使用氯化化合物而引起环境问题。本文中，使用silicatein-α（Silα）证明了PDMS合成的生物催化方法，所述silicatein-α（Silα）是一种来自海绵的酶，已知其催化Si-O键的水解和缩合。使用二烷氧基硅烷前体，发现Silα在非水介质中催化PDMS的形成，产生具有更高分子量（约1000-2000 Da）的聚合物。然而，在长时间暴露后，也观察到聚合物逐渐降解。总之，这些观察结果表明Silα催化聚硅氧烷的形成，证明了生物催化在更可持续的聚硅氧烷生产中的潜力。
Polysiloxanes, with poly(dimethyl)siloxane (PDMS) being the most common example, are widely used in various industrial and consumer applications due to the physicochemical properties imparted by their Si–O–Si backbone structure. The conventional synthesis of PDMS involves the hydrolysis of dichlorodimethylsilane, which raises environmental concerns due to the usage of chlorinated compounds. Herein, a biocatalytic approach for PDMS synthesis is demonstrated using silicatein-α (Silα), an enzyme from marine sponges that is known to catalyse the hydrolysis and condensation of Si–O bonds. Using dialkoxysilane precursors, it was found that Silα catalyses the formation of PDMS in non-aqueous media, yielding polymers with higher molecular weights (approximately 1000–2000 Da). However, on prolonged exposure, the gradual degradation of the polymers was also observed. Overall these observations indicate that Silα catalyses the formation polysiloxanes, demonstrating the potential of biocatalysis for more sustainable polysiloxane production.