Development and Validation of a Brain Phantom for Therapeutic Cooling Devices
Development and Validation of a Brain Phantom for Therapeutic Cooling Devices
复制标题
用于治疗冷却装置的大脑模型的开发和验证
DOI：
10.1115/1.4036215
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Scott Gayzik, F.
中科院分区：
文献类型：
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作者：
Packett, Ryan D.;Brown, Philip J.;Popli, Gautam S.;Scott Gayzik, F.
组织冷却已被证明是多种疾病和损伤的可行疗法，并已应用于大脑治疗癫痫和脑震荡，从而改善了长期结果。为了便于研究温度降低作为各种冷却方法的函数，开发和分析了热脑体模。体模由钾中和的高吸水性共聚物水凝胶组成。在一系列冷却试验中使用冷却块和37度水对体模进行测试，代表范围高达6 gph的无方向血流，这是基于原型体积的生理学代表性范围。结果进行了比较，对一个有效的有限差分（FD）模型。在FD模型中使用了两组参数：一组代表体模本身，另一组代表脑实质。然后使用该模型计算体模和大脑模型在5 mm深度处所有流速的稳态冷却。进行这项工作是为了（1）根据体模结果验证FD模型，以及（2）评价体模的热响应与灌注脑的热响应的相似程度。FD体模模型与经验体模结果吻合良好。此外，在生理流量下，经验体模与预测的脑响应在3.5%内一致，表明生物热响应。该模型将被用作未来研究应用于大脑皮层的热介导疗法的平台。
Tissue cooling has been proven as a viable therapy for multiple conditions and injuries and has been applied to the brain to treat epilepsy and concussions, leading to improved long-term outcomes. To facilitate the study of temperature reduction as a function of various cooling methods, a thermal brain phantom was developed and analyzed. The phantom is composed of a potassium-neutralized, superabsorbent copolymer hydrogel. The phantom was tested in a series of cooling trials using a cooling block and 37 deg water representing nondirectional blood flow ranging up to 6 gph, a physiologically representative range based on the prototype volume. Results were compared against a validated finite difference (FD) model. Two sets of parameters were used in the FD model: one set to represent the phantom itself and a second set to represent brain parenchyma. The model was then used to calculate steady-state cooling at a depth of 5 mm for all flow rates, for both the phantom and a model of the brain. This effort was undertaken to (1) validate the FD model against the phantom results and (2) evaluate how similar the thermal response of the phantom is to that of a perfused brain. The FD phantom model showed good agreement with the empirical phantom results. Furthermore, the empirical phantom agreed with the predicted brain response within 3.5% at physiological flow, suggesting a biofidelic thermal response. The phantom will be used as a platform for future studies of thermally mediated therapies applied to the cerebral cortex.