Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2.
Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2.
复制标题
感染结核分枝杆菌的小鼠对 SARS-CoV-2 的继发感染具有抵抗力。
DOI：
10.1101/2021.11.09.467862
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Robinson,RichardT
中科院分区：
文献类型：
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作者：
Mejia,OscarRosas;Gloag,ErinS;Li,Jianying;Ruane-Foster,Marisa;Claeys,TiffanyA;Farkas,Daniela;Farkas,Laszlo;Xin,Gang;Robinson,RichardT
结核分枝杆菌（Mycobacterium tuberculosis，Mtb）和SARS-CoV-2（SARS-CoV-2，CoV 2）是导致感染性疾病死亡的主要原因。虽然Mtb和CoV 2都引起严重的，有时是致命的呼吸道感染，但Mtb感染及其相关的免疫应答对CoV 2继发感染的影响尚不清楚。为了解决这个问题，我们应用了COVID 19的两种小鼠模型，使用慢性感染Mtb的小鼠。在这两种模型系统中，Mtb感染的小鼠对继发性CoV 2感染及其病理后果具有抗性，并且CoV 2感染不影响Mtb负荷。共感染和单感染肺的单细胞RNA测序证明Mtb感染小鼠的抗性与病毒攻击后T和B细胞亚群的扩增相关。总的来说，这些数据表明Mtb感染以不利于CoV 2存活的方式调节肺环境。
Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immune response on secondary infection with CoV2 is unknown. To address this question we applied two mouse models of COVID19, using mice which were chronically infected with Mtb. In both model systems, Mtb-infected mice were resistant to secondary CoV2 infection and its pathological consequences, and CoV2 infection did not affect Mtb burdens. Single cell RNA sequencing of coinfected and monoinfected lungs demonstrated the resistance of Mtb-infected mice is associated with expansion of T and B cell subsets upon viral challenge. Collectively, these data demonstrate that Mtb infection conditions the lung environment in a manner that is not conducive to CoV2 survival.