THE DEPRESSION OF SPINAL INHIBITION BY MORPHINE
THE DEPRESSION OF SPINAL INHIBITION BY MORPHINE
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DOI：
10.1007/bf01990015
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发表时间：
1969-01-01
期刊：
影响因子：
--
通讯作者：
DUGGAN A W
中科院分区：
文献类型：
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作者：
CURTIS D R;DUGGAN A W
电泳给药吗啡和可待因，而不是哌替啶，阻断了甘氨酸对脊髓神经元的抑制作用，但不降低GABA的有效性。吗啡的这种作用与士的宁相似，但比士的宁弱得多。当分剂量静脉注射吗啡以避免明显的循环障碍时，吗啡以平行的方式减少了脊髓运动神经元的直接和复发性抑制。同样，吗啡是一种非常弱的士的宁类物质，需要超过50毫克/公斤的剂量才能阻断这些失突触性脊髓抑制。结果与甘氨酸样氨基酸作为直接和复发脊髓抑制途径的抑制递质的功能并不矛盾。
Electrophoretically administered morphine and codeine, but not meperidine, blocked the inhibitory effect of glycine on spinal neurones, without reducing the effectiveness of GABA. This action of morphine was similar to, but much weaker than, that of strychnine.When administered intravenously in divided doses to circumvent marked circulatory disturbances, morphine reduced the direct and recurrent inhibition of spinal motoneurones in a parallel fashion. Again morphine was a very weak strychnine-like substance, doses in excess of 50 mg/kg being required to block these disynaptic spinal inhibitions.The results are not incompatible with the function of a glycine-like amino acid as the inhibitory transmitter for both the direct and recurrent spinal inhibitory pathway.