Distinct neuroinflammatory profile in post-mortem human Huntington's disease
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
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DOI：
10.1097/wnr.0b013e32832e34ee
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发表时间：
2009-08-05
期刊：
影响因子：
1.7
通讯作者：
Moeller, Thomas
中科院分区：
文献类型：
--
作者：
Silvestroni, Aurelio;Faull, Richard L. M.;Moeller, Thomas
神经炎症是许多神经退行性疾病的一个显著特征，然而，对亨廷顿氏病的神经炎症知之甚少。我们使用实时定量聚合酶链式反应来比较死后亨廷顿病患者和对照组的纹状体、皮质和小脑中神经炎症相关介质的表达水平。我们发现包括CCL2和IL-10在内的几种关键炎症介质的表达增加，特别是在亨廷顿病患者的纹状体，这是受这种病理影响的主要区域。值得注意的是，我们还发现IL-6、IL-8和MMP9在大脑皮层上调，特别是小脑，这是通常被认为是亨廷顿病幸免于难的大脑区域。我们的数据表明，神经炎症是亨廷顿病的一个显著特征，可能成为治疗干预的新靶点。神经报告20：1098-1103(C)2009沃尔特斯·克鲁沃健康垂直酒吧Lippincott Williams&Wilkins。
Neuroinflammation is a prominent feature of many neurodegenerative diseases, however, little is known about neuroinflammation in Huntington's disease. We used quantitative real time-PCR to compare the expression level of neuroinflammation-associated mediators in the striatum, cortex, and cerebellum from post-mortem Huntington's disease patient samples with controls. We found increased expression of several key inflammatory mediators, including CCL2 and IL-10, specifically in the striatum of Huntington's disease patients, the main area affected by this pathology. Remarkably, we also found upregulation of IL-6, IL-8, and MMP9, in the cortex and notably the cerebellum, a brain area commonly thought to be spared by Huntington's disease. Our data suggest that neuroinflammation is a prominent feature associated with Huntington's disease and may constitute a novel target for therapeutic intervention. NeuroReport 20:1098-1103(C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.