Biology of feline leukemia virus in the natural environment.
Biology of feline leukemia virus in the natural environment.
复制标题
自然环境中猫白血病病毒的生物学。
作者：
W. Hardy;P. Hess;E. MacEwen;A. McClelland;E. Zuckerman;M. Essex;S. Cotter;O. Jarrett
猫白血病病毒（FeLV）于1964年在一群患有淋巴肉瘤的猫中被发现。观察到的猫淋巴肉瘤病例聚集表明FeLV是猫的一种传染因子。开发了一种简单的FeLV免疫荧光试验，可以对生活在自然环境中的猫的病毒分布进行血清流行病学研究。对2000多只猫进行了测试，结果明确表明FeLV是猫的一种传染性病原体。这一发现现已通过三种不同的测试程序得到独立证实。在FeLV的传染性被发现后，一种简单的FeLV测试和去除程序被设计出来，以控制病毒在自然环境中的传播。通过清除感染FeLV的猫，在45个家庭中控制了FeLV的传播，而在25个家庭中，让感染的猫与未感染的猫接触，12%未感染的猫被感染。最终控制FeLV需要开发出一种有效的FeLV疫苗，现在看来这是可行的，因为我们已经对一些猫进行了减毒FeLV的实验免疫。虽然FeLV对猫具有传染性，但没有证据表明FeLV可以感染人类。
The feline leukemia virus (FeLV) was discovered in 1964 in a cluster of cats with lymphosarcoma. The observed clustering of cases of feline lymphosarcoma suggested that FeLV was an infectious agent for cats. The development of a simple immunofluorescent test for FeLV permitted a seroepidemiological study to be undertaken on the distribution of the virus in cats living in their natural environment. Over 2000 cats were tested, and the results showed conclusively that FeLV is an infectious agent for cats. This finding has now been independently confirmed using three different test procedures. After the infectious nature of FeLV was discovered, a simple FeLV test and removal program was devised to control the spread of the virus in the natural environment. The spread of FeLV was controlled in 45 households by removing the FeLV-infected cats, while in 25 households, where the infected cats were left in contact with the uninfected cats, 12% of the uninfected cats became infected. The ultimate control of FeLV awaits the development of an effective FeLV vaccine, which now seems feasible since we have already experimentally immunized some cats with attenuated FeLV. Although FeLV is infectious for cats there is no evidence that FeLV can infect humans.