Mononuclear cells in malignant and benign human breast tissue.
Mononuclear cells in malignant and benign human breast tissue.
复制标题
恶性和良性人类乳腺组织中的单核细胞。
DOI：
--
复制
发表时间：
1983
影响因子：
4.6
通讯作者：
R. Giorno
中科院分区：
文献类型：
--
作者：
R. Giorno
应用单克隆抗体和免疫酶技术研究了乳腺良恶性组织中单个核细胞浸润。浸润性导管癌含有主要由T淋巴细胞组成的单核细胞浸润，以及少量B细胞和巨噬细胞群体。最占优势的T细胞亚群是T8，细胞毒性抑制细胞。一些肿瘤含有T6阳性细胞，可能是未成熟的T细胞。良性纤维性乳腺病的间质淋巴细胞以T细胞为主，但以T4细胞为主，未检出T6细胞。在良性乳腺组织中发现了上皮内淋巴细胞。上皮内淋巴细胞是T细胞，具有T8表型的极大优势。T6阳性细胞也被确定在上皮内，但他们似乎代表肌上皮细胞，而不是不成熟的T细胞。
The mononuclear cell infiltrate in benign and malignant breast tissue was studied using monoclonal antibodies with an immunoenzymatic technique. Infiltrating duct carcinomas contained a mononuclear cell infiltrate made up mostly of T lymphocytes, with minor B-cell and macrophage populations. The most preponderant T-cell subset was the T8, cytotoxic-suppressor cell. Some tumors contained T6-positive cells, possibly immature T cells. In contrast, stromal lymphocytes in benign fibrous mastopathy were largely T cells, but the T4, helper-inducer cell was the most preponderant, and T6 cells were not detected. Intraepithelial lymphocytes were identified in benign breast tissue. Intraepithelial lymphocytes are T cells, with a great preponderance of the T8 phenotype. The T6-positive cells were also identified within the epithelium, but they seemed to represent myoepithelial cells rather than immature T cells.