Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans.
Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans.
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DOI：
10.1136/acupmed-2014-010730
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Sun J;Li X;Yang C;Wang Y;Shi F;Gao Y;Luan Q;Zhu Y;Sun X
太空飞行与心血管失调有关。然而，微重力对心血管系统的影响及其机制和对策仍然未知。我们以前的研究表明，经皮电针刺激（TEAS）是有效的改善立位耐力（OT）。本研究的目的是确定TEAS治疗是否可以减轻由4天−6°头低位卧床休息（HDBR）引起的心血管失调。将14名健康男性随机分为对照组（n=6）和TEAS治疗组（n=8）。对照组在HDBR 4天期间不采取任何措施; TEAS治疗组在HDBR 4天期间每天在内关（PC6）进行TEAS 30 min，连续4天。 分别于HDBR前后测定OT、血浆激素、血浆容量和心率变异性。分别于HDBR前、中、后测定心功能和脑血流量。数据显示，TEAS治疗减轻了对照组中观察到的OT和心脏功能的降低，减轻了自主神经功能障碍，并部分防止了HDBR后的血浆容量减少。TEAS组HDBR后血管紧张素II和醛固酮分别增加129.3%和133.3%（P<0.05）。这些结果表明，在PC6每天30分钟的TEAS治疗在维持OT方面部分有效，这可能是由于血浆容量调节激素增加和外周交感神经系统的激活。 TEAS治疗在减少HDBR诱导的心血管失调4天方面似乎是有效的。 NCT02300207。
Spaceflight is associated with cardiovascular deregulation. However, the influence of microgravity on the cardiovascular system and its mechanisms and countermeasures remain unknown. Our previous studies have demonstrated that transcutaneous electrical acupuncture stimulation (TEAS) is effective in improving orthostatic tolerance (OT). The purpose of this study was to determine if TEAS treatment can attenuate cardiovascular deconditioning induced by a 4-day −6° head-down bed rest (HDBR). Fourteen healthy male subjects were randomly allocated to a control group (control, n=6, 4 days HDBR without countermeasures) and a TEAS treatment group (TEAS, n=8, 4 days HDBR with TEAS at Neiguan (PC6) for 30 min each day for 4 consecutive days during HDBR). OT, plasma hormones, plasma volume and heart rate variability were assessed before and after HDBR. Cardiac function and cerebral blood flow were measured before, during and after HDBR. The data showed that TEAS treatment mitigated the decrease in OT that was observed in the control group and cardiac function, alleviated autonomic dysfunction, and partially prevented plasma volume reduction after HDBR. Angiotensin II and aldosterone were significantly increased by 129.3% and 133.3% after HDBR in the TEAS group (p<0.05). These results indicate that 30 min of daily TEAS treatment at PC6 is partially effective in maintaining OT, probably due to increased plasma volume-regulating hormones and activation of the peripheral sympathetic nervous system. TEAS treatment appears effective at reducing cardiovascular deconditioning induced by HDBR for 4 days. NCT02300207.