Fluoxetine in the treatment of intention myoclonus.
Fluoxetine in the treatment of intention myoclonus.
复制标题
氟西汀治疗意向性肌阵挛。
DOI：
10.1097/00002826-198303000-00005
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发表时间：
1983
影响因子：
1
通讯作者：
Chung,E
中科院分区：
文献类型：
--
作者：
VanWoert,MH;Magnussen,I;Rosenbaum,D;Chung,E
Some types of intention myoclonus respond to serotonin precursor therapy (eg, L-5-hydroxytryptophan, L-5HTP). Fluoxetine, a specific serotonin (5HT) uptake blocker, was found to have no antimyoclonic effect when administered by itself to four patients with intention myoclonus. However, in two patients with intention myoclonus responsive to L-5HTP and carbidopa, fluoxetine reduced the required dose of L-5HTP to approximately one-third, with greater antimyoclonic activity, decreased side effects, and reduction in platelet 5HT and plasma 5-hydroxyindoleacetic acid and L-5HTP concentrations. These findings further support the hypothesis that some forms of intention myoclonus are caused by a deficiency of brain 5HT, and suggest that the addition of fluoxetine to L-5HTP and carbidopa may improve antimyoclonic therapy.
