Functional and structural synergy for resolution recovery and partial volume correction in brain PET
Functional and structural synergy for resolution recovery and partial volume correction in brain PET
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DOI：
10.1016/j.neuroimage.2008.09.012
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发表时间：
2009-01-15
期刊：
影响因子：
5.7
通讯作者：
Turkheimer, Federico E.
中科院分区：
文献类型：
--
作者：
Shidahara, Miho;Tsoumpas, Charalampos;Turkheimer, Federico E.
目的：正电子发射断层扫描（PET）具有独特的脑功能测量能力，但由于分辨率低和缺乏形态学细节，影响了其临床应用潜力。在这里，我们提出并评估了一种小波协同方法，该方法结合了来自多个来源（CT， MRI和解剖概率地图集）的功能和结构信息，用于准确定量恢复PET图像中的放射性浓度。当该方法与解剖概率图谱相结合时，结果是对部分体积效应进行功能体积校正。方法：基于小波变换的多分辨率特性，提出一种基于小波变换的多分辨率方法。首先，将目标PET图像和相应的解剖图像（CT/MRI/基于atlas的分割MRI）分解为多个分辨率元素。其次，在适当缩放后，将PET图像的部分高分辨率分量替换为解剖图像的高分辨率分量。结构输入的量由两种模态的相对高频信号内容加权。该方法在数字Zubal假体和临床数据上进行了验证，以评估其定量潜力。结果：模拟研究显示，功能恢复与提供的正确结构细节的数量之间存在预期的关系，当使用真实图像作为解剖参考时，可以实现完美的恢复。使用T1-MRI图像可显著提高PET图像分辨率。然而，当使用基于地图集的分割图像作为解剖学参考时，改进是最大的；这些结果在临床数据集中得到了重复。结论：功能和结构数据的协同使用，特别是解剖学概率信息的结合，产生了质量精美的形态学校正的PET图像。(C) 2008爱思唯尔公司版权所有。
Purpose: Positron Emission Tomography (PET) has the unique capability of measuring brain function but its clinical potential is affected by low resolution and lack of morphological detail. Here we propose and evaluate a wavelet synergistic approach that combines functional and structural information from a number of sources (CT, MRI and anatomical probabilistic atlases) for the accurate quantitative recovery of radioactivity concentration in PET images. When the method is combined with anatomical probabilistic atlases, the outcome is a functional volume corrected for partial volume effects.Methods: The proposed method is based on the multiresolution property of the wavelet transform. First, the target PET image and the corresponding anatomical image (CT/MRI/atlas-based segmented MRI) are decomposed into several resolution elements. Secondly, high-resolution components of the PET image are replaced, in part, with those of the anatomical image after appropriate scaling. The amount of structural input is weighted by the relative high frequency signal content of the two modalities. The method was validated on a digital Zubal phantom and clinical data to evaluate its quantitative potential.Results: Simulation studies showed the expected relationship between functional recovery and the amount of correct structural detail provided, with perfect recovery achieved when true images were used as anatomical reference. The use of T1-MRI images brought significant improvements in PET image resolution. However improvements were maximized when atlas-based segmented images as anatomical references were used; these results were replicated in clinical data sets.Conclusion: The synergistic use of functional and structural data, and the incorporation of anatomical probabilistic information in particular, generates morphologically corrected PET images of exquisite quality. (C) 2008 Elsevier Inc. All rights reserved.