Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT.
Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT.
复制标题
儿童期因血液疾病接受骨髓移植的患者的最终身高：迟发效应工作组-EBMT 的一项研究。
DOI：
10.1182/blood.v93.12.4109.412k13_4109_4115
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发表时间：
1999
期刊：
影响因子：
20.3
通讯作者：
G. Socié
中科院分区：
文献类型：
--
作者：
A. Cohen;A. Rovelli;B. Bakker;C. Uderzo;M. T. Lint;H. Esperou;A. Gaiero;A. Leiper;R. Dopfer;J. Cahn;F. Merlo;H. Kolb;G. Socié
关于骨髓移植（BMT）对生长的长期影响的数据很少。本研究探讨了那些在儿童时期接受BMT的患者最终身高结局中发挥作用的因素。分析了230名再生障碍性贫血、白血病和淋巴瘤患者中181名在青春期前接受BMT（平均年龄，9.8 ± 2.6岁）并已达到最终身高的患者的数据。与骨髓移植身高（P < 10（7））和遗传身高（P < 10（7））相比，最终身高标准差评分（SDS）值总体下降。女孩比男孩做得更好，而且在BMT时年龄越小，身高损失越大。既往头颅照射+单次全身照射对最终身高的影响最大（P < 10（4））。TBI的分级显著降低了这种效应，白消安和环磷酰胺的预处理似乎可以消除这种效应。移植类型、移植物抗宿主病、生长激素或类固醇治疗不影响最终身高。辐射，男性性别和年轻的BMT被认为是长期身高损失的主要因素。然而，大多数患者（140/181）已达到成人身高，在一般人群的正常范围内。
Few data are available on the long-term effect of bone marrow transplantation (BMT) on growth. This study examines those factors that play a role in the final height outcome of patients who underwent BMT during childhood. Data on 181 of 230 patients with aplastic anemia, leukemias, and lymphomas who had BMT before puberty (mean age, 9.8 +/- 2.6 years) and who had reached their final height were analyzed. An overall decrease in final height standard deviation score (SDS) value was found compared with the height at BMT (P < 10(7)) and with the genetic height (P < 10(7)). Girls did better than boys, and the younger in age the person was at time of BMT, the greater the loss in height. Previous cranial irradiation + single-dose total body irradiation (TBI) caused the greatest negative effect on final height achievement (P < 10(4)). Fractionation of TBI reduces this effect significantly and conditioning with busulfan and cyclophosphamide seems to eliminate it. The type of transplantation, graft-versus-host disease, growth hormone, or steroid treatment did not influence final height. Irradiation, male gender and young age at BMT were found to be major factors for long-term height loss. Nevertheless, the majority of patients (140/181) have reached adult height within the normal range of the general population.
骨髓移植治疗肝炎相关再生障碍性贫血：长期幸存者的随访。
DOI：
--
发表时间：
1996
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Kiem,HP;McDonald,GB;Myerson,D;Spurgeon,CL;Deeg,HJ;Sanders,JE;Doney,K;Appelbaum,FR;Sullivan,KM;Witherspoon,RP;Storb,R
通讯作者：
Storb,R
影响因子：
20.3
作者：
Sanders,JE;Pritchard,S;Mahoney,P;Amos,D;Buckner,CD;Witherspoon,RP;Deeg,HJ;Doney,KC;Sullivan,KM;Appelbaum,FR
通讯作者：
Appelbaum,FR
骨髓移植后儿童的生长：白消安加环磷酰胺与环磷酰胺加全身照射。
影响因子：
20.3
作者：
Wingard,JR;Plotnick,LP;Freemer,CS;Zahurak,M;Piantadosi,S;Miller,DF;Vriesendorp,HM;Yeager,AM;Santos,GW
通讯作者：
Santos,GW