Role of risperidone in children with autism spectrum disorder
Role of risperidone in children with autism spectrum disorder
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DOI：
10.1345/aph.1g389
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发表时间：
2006-05-01
影响因子：
2.9
通讯作者：
Rey, Jose A.
中科院分区：
文献类型：
--
作者：
Chavez, Benjamin;Chavez-Brown, Mapy;Rey, Jose A.
目的：回顾利培酮治疗儿童自闭症谱系障碍（ASD）的有效性和安全性的临床试验。数据来源：检索MEDLINE/PubMed（1992- 2006年2月），以及大量的期刊人工综述，使用关键词自闭症和利培酮。研究选择和数据提取：仅纳入双盲、安慰剂对照试验。资料综合：ASD是最常见的广泛性发育障碍。自闭症的主要特征（核心症状）是社交技能障碍、沟通问题和刻板动作。行为表现或适应不良行为包括攻击性、易怒、多动、注意力不集中、冲动、发脾气和自残行为。结论：根据所检查的数据，利培酮似乎对治疗自闭症的某些行为方面有效且安全，包括易怒、攻击、多动和刻板印象。它似乎对治疗自闭症的核心症状并不有效。
OBJECTIVE: To review the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autism spectrum disorder (ASD).DATA SOURCES: Searches of MEDLINE/PubMed (1992-February 2006) were conducted, as well as an extensive manual review of journals, using the key words autism and risperidone.STUDY SELECTION AND DATA E)EXTRACTION: Only double-blind, placebo-controlled trials were included for review.DATA SYNTHESIS: ASD is the most common of the pervasive developmental disorders. The main characteristics (core symptoms) of autism are impairment in social skills, problems communicating, and stereotypical movements. Behavioral manifestations or maladaptive behaviors include aggression, irritability, hyperactivity, inattention, impulsivity, tantrums, and self-injurious behavior.CONCLUSIONS: Based on the data examined, risperidone appears efficacious and safe for treating certain behavioral aspects of autism including irritability, aggression, hyperactivity, and stereotypy. It does not appear to be as effective for the treatment of the core symptoms of autism.