A case of severe soft tissue infection due to Streptococcus tigurinus diagnosed by necropsy in which genomic analysis was useful for clarifying its pathogenicity.
A case of severe soft tissue infection due to Streptococcus tigurinus diagnosed by necropsy in which genomic analysis was useful for clarifying its pathogenicity.
复制标题
一例通过尸检诊断为老虎链球菌引起的严重软组织感染的病例，其中基因组分析有助于阐明其致病性。
DOI：
10.1111/pin.12656
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Matsumoto H.
中科院分区：
文献类型：
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作者：
Yoshizawa H;Motooka D;Matsumoto Y;Katada R;Nakamura S;Morii E;Iida T;Matsumoto H.
在严重感染性死亡中，病原微生物的死后检测对于诊断死因以及公共卫生非常重要。然而，很难识别从死后材料中检测到的微生物是否真正致病。我们报告一例严重的软组织感染，由于链球菌口腔亚种tigurinus（S。tigurinus），最近报道的物种，其中进行全基因组分析以阐明其致病性。一名46岁的妇女死于严重传染病的症状。验尸官进行了尸检。外部结果表明软组织感染;随后，尸检采集的病理标本显示与坏死性筋膜炎一致的结果。在死后细菌试验中，S.从局部尸检样本中检测到tigurinus。通过全基因组测序分析其致病性，并检测到一株S.作为基因注释的结果，tigurinus具有对其高毒力菌株特异性和独特的遗传决定簇。利用各种技术，如全基因组测序，可能是准确和安全地诊断感染性死亡原因的有力工具。
Post‐mortem detection of pathogenetic microorganisms in severe infectious death is significantly important for diagnosing the cause of death as well as for public health. However, it is difficult to recognize whether a microorganism detected from post‐mortem materials is truly pathogenic or not. We report a case of severe soft tissue infection due toStreptococcus oralissubsp.tigurinus(S. tigurinus), a recently reported species, in which whole‐genome analysis was performed to clarify its pathogenicity. A 46‐year‐old woman had died with symptoms of a severe infectious disease. A post‐mortem examination was performed by a medical examiner. The external findings suggested a soft tissue infection; subsequently, pathological specimens sampled by necropsy revealed findings compatible with necrotizing fasciitis. In the post‐mortem bacterial test,S. tigurinuswas detected from the localized autopsy sample. Whole‐genome sequencing was performed to analyze its pathogenicity and detected a strain ofS. tigurinuswith genetic determinants that were specific and unique to its highly virulent strains as a result of gene annotation. Utilizing various technologies, such as whole‐genome sequencing, may be a powerful tool for diagnosing the cause of infectious death accurately and safely.