The Cerebrospinal Fluid Levels of Tau, Growth-Associated Protein-43 and Soluble Amyloid Precursor Protein Correlate in Alzheimer’s Disease, Reflecting a Common Pathophysiological Process
The Cerebrospinal Fluid Levels of Tau, Growth-Associated Protein-43 and Soluble Amyloid Precursor Protein Correlate in Alzheimer’s Disease, Reflecting a Common Pathophysiological Process
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DOI：
10.1159/000051268
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发表时间：
2001-05
影响因子：
2.4
通讯作者：
M. Sjögren;P. Davidsson;J. Gottfries;H. Vanderstichele;Å. Edman;E. Vanmechelen;A. Wallin;K. Blennow
中科院分区：
文献类型：
--
作者：
M. Sjögren;P. Davidsson;J. Gottfries;H. Vanderstichele;Å. Edman;E. Vanmechelen;A. Wallin;K. Blennow
研究了额颞叶痴呆 (FTD; n = 14)、阿尔茨海默病 (AD; n = 47) 和血管性痴呆患者脑脊液 (CSF) 中 tau（总 tau）、生长相关蛋白 43 (GAP-43)、可溶性淀粉样前体蛋白 (sAPP；即总 sAPP) 和 β-淀粉样蛋白 42 (Aβ42) 的水平（VAD；n = 16），以及年龄匹配的对照（n = 12）。与对照组和 FTD 相比，AD 中的 CSF-tau 增加（两者均 p < 0.001）。与对照组相比，AD 中的 CSF-GAP-43 增加（p < 0.05），与 FTD 相比，AD 中的 CSF-GAP-43 和 CSF-sAPP 均增加（p < 0.01）。所有组中的 CSF-tau 和 CSF-GAP-43 之间以及 AD 中的 CSF-tau、CSF-GAP-43 和 CSF-sAPP 之间均发现正相关且高度显着的相关性。发现的相关性可能反映了常见的病理生理过程，例如轴突变性。
Cerebrospinal fluid (CSF) levels of tau (total tau), growth-associated protein-43 (GAP-43), soluble amyloid precursor protein (sAPP; i.e. total sAPP), and β-amyloid42 (Aβ42) were studied in patients with frontotemporal dementia (FTD; n = 14), Alzheimer’s disease (AD; n = 47) and vascular dementia (VAD; n = 16), and in age-matched controls (n = 12). CSF-tau was increased in AD compared to controls and FTD (p < 0.001 for both). CSF-GAP-43 was increased in AD compared to controls (p < 0.05), and both CSF-GAP-43 and CSF-sAPP were increased in AD compared to FTD (p < 0.01). Positive and highly significant correlations were found between CSF-tau and CSF-GAP-43 in all groups and between CSF-tau, CSF-GAP-43 and CSF-sAPP in AD. The correlations found may reflect a common pathophysiologic process such as axonal degeneration.