Complement-Mediated Regulation of Metabolism and Basic Cellular Processes.
Complement-Mediated Regulation of Metabolism and Basic Cellular Processes.
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DOI：
10.1016/j.immuni.2016.08.003
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发表时间：
2016-08-16
期刊：
影响因子：
32.4
通讯作者：
Kemper C
中科院分区：
文献类型：
--
作者：
Hess C;Kemper C
补体被认为是先天免疫的关键武器。它是清除入侵病原体所必需的，并通过直接破坏病原体和激活先天性和适应性免疫细胞发挥作用。然而，补体的激活和功能并不局限于细胞外空间，也发生在细胞内。最近的研究表明，补体激活调节关键的代谢途径，从而可以影响细胞的基本过程，如生存，增殖和自噬。新鉴定的补体功能包括在形成代谢重编程中的关键作用，这是T细胞效应子分化的基础，以及作为与其他效应子系统相互作用的联系的作用，特别是炎性小体和Notch转录因子网络。本文综述了补体对细胞基本过程的贡献，特别是补体与细胞代谢的整合，以及在感染和其他疾病环境中的潜在意义。
Complement is well appreciated as critical arm of innate immunity. It is required for the removal of invading pathogens and functions by direct pathogen destruction and through the activation of innate and adaptive immune cells. However, complement activation and function is not confined to the extracellular space but also occurs within cells. Recent work indicates that complement activation regulates key metabolic pathways and thus can impact fundamental processes of the cell, such as survival, proliferation, and autophagy. Novel identified functions of complement include a key role in shaping metabolic reprogramming, which underlies T cell effector differentiation, and a role as a nexus for interactions with other effector systems, in particular the inflammasome and Notch transcription factor networks. This review focuses on the contributions of complement to basic processes of the cell, in particular the integration of complement with cellular metabolism, and the potential implications in infection and other disease settings.