In vivo imaging of transplanted stem cells in the central nervous system.
In vivo imaging of transplanted stem cells in the central nervous system.
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DOI：
10.1016/j.gde.2014.09.007
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发表时间：
2014-10
影响因子：
4
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Duffy BA;Weitz AJ;Lee JH
体内成像越来越多地用于研究神经系统疾病的干细胞治疗。直接标记用于临床前和临床研究，以跟踪移植细胞的命运。为了进一步确定细胞活力，实验研究可以利用报告基因技术。结构和功能脑成像也可以与细胞成像一起用作治疗效果的生物标志物。此外，新的成像技术有可能用于监测干细胞来源的细胞与宿主神经系统的功能整合。在这篇综述中，我们研究了这些领域的最新进展，并确定了干细胞治疗和神经成像界面的未来研究的有希望的方向。
In vivo imaging is increasingly being utilized in studies investigating stem cell-based treatments for neurological disorders. Direct labeling is used in preclinical and clinical studies to track the fate of transplanted cells. To further determine cell viability, experimental studies are able to take advantage of reporter gene technologies. Structural and functional brain imaging can also be used alongside cell imaging as biomarkers of treatment efficacy. Furthermore, it is possible that new imaging techniques could be used to monitor functional integration of stem cell-derived cells with the host nervous system. In this review, we examine recent developments in these areas and identify promising directions for future research at the interface of stem cell therapies and neuroimaging.