The telomeric transcriptome: From fission yeast to mammals
The telomeric transcriptome: From fission yeast to mammals
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DOI：
10.1016/j.biocel.2012.03.021
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发表时间：
2012-07-01
影响因子：
4
通讯作者：
Azzalin, Claus M.
中科院分区：
文献类型：
--
作者：
Bah, Amadou;Azzalin, Claus M.
线性真核染色体的末端转录成不同种类的非编码转录物（端粒转录组），包括TERRA（含端粒重复序列的RNA）分子;然而，与端粒转录组相关的功能仍然难以捉摸。在过去几年中积累的实验证据表明，在端粒的完整性或染色体末端的异染色质状态被改变的细胞中，端粒的转录活性被改变。相反，端粒的转录似乎不受其长度的影响。在本文中，我们简要地回顾了目前的知识状态的组成，生物起源和调控的端粒转录组从酵母到人类。我们还提出了一个模型，其中TERRA是由功能失调的端粒引发的DNA损伤反应的一部分，并讨论了端粒转录在人类病理学发展中的潜在参与。(C)2012爱思唯尔有限公司保留所有权利。
The ends of linear eukaryotic chromosomes are transcribed into different species of non-coding transcripts (the telomeric transcriptome), including TERRA (telomeric repeat-containing RNA) molecules; however, the functions associated with the telomeric transcriptome remain elusive. Experimental evidence accumulated during the past few years indicates that the transcriptional activity of telomeres is changed in cells in which the integrity of the telomeres or the heterochromatic state of chromosome ends is altered. On the contrary transcription of a telomere appears not to be influenced by its length. In this paper we briefly review the current state of knowledge on the composition, biogenesis, and regulation of the telomeric transcriptome from yeasts to humans. We also suggest a model in which TERRA is part of the DNA damage response triggered by dysfunctional telomeres and discuss the potential involvement of telomere transcription in the development of human pathologies. (C) 2012 Elsevier Ltd. All rights reserved.